Arts, entertainment, and media
* Ubiquitous Synergy Seeker, a Canadian band * Universal Studios Singapore, a theme park in SingaporeBusinesses and organizations
* Union of Sovereign States, the planned successor to the Soviet Union * Union Switch & Signal, a supplier of railroad switching equipment * Union Syndicale Suisse, the Swiss Trade Union Confederation * United Seamen's Service, a non-profit, federally chartered organization founded in 1942 * United State of Saurashtra, a separate, western State within the Union of India from 1948 until 1956 *Computing
* Unformatted System Services, the mechanism within VTAM to format a session's logmode and application. An equivalent facility in TN3270 also specifies a logon screen. * UNIX System Services, a component of z/OS that provides Unix compatibility * Upload Speed Sense, a method of regulating a host's upload bandwidth in theHealth care
* Ultrasound scan, a scientific and medical imaging technique (usually refers to medical ultrasound) * Upshaw–Schulman syndrome, the recessively inherited form of thrombotic thrombocytopenic purpura * Universal Spinal System, an implantable device (instrumentation) system for correcting scoliosisSchools
* University of Southern Somalia * Uxbridge Secondary School, a high school in Uxbridge, Ontario, CanadaOther uses
* United States Ship, typically as a ship prefix in the United States Navy (includes submarines) * United States Standard, an older standard of screw thread * In the fictional ''