USP8
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Ubiquitin carboxyl-terminal hydrolase 8 is an
enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''USP8''
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.


Interactions

USP8 has been shown to interact with RNF41 and
STAM2 Signal transducing adapter molecule 2 is a protein that in humans is encoded by the ''STAM2'' gene. Function The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine rece ...
.


Diseases

In a few cases of Morbus Cushing's disease, a mutation of USP8 has been found.


References


Further reading

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