Ubiquitin carboxyl-terminal hydrolase 15 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
that in humans is encoded by the ''USP15''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Ubiquitin is a highly conserved protein involved in the regulation of intracellular
protein breakdown
In molecular biology, protein catabolism is the breakdown of proteins into smaller peptides and ultimately into amino acids. Protein catabolism is a key function of digestion process. Protein catabolism often begins with pepsin, which converts p ...
,
cell cycle
The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA ( DNA replication) and some of its organelles, and sub ...
regulation, and stress response, which is released from degraded proteins by disassembly of the
polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).
See also
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USP1
Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the ''USP1'' gene.
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His an ...
(MIM 603478).
References
Further reading
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