Upstream stimulatory factor 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''USF2''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through Pyridine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.
Interactions
USF2 has been shown to
interact with
USF1 (human gene)
Upstream stimulatory factor 1 is a protein that in humans is encoded by the ''USF1'' gene.
Gene
The upstream stimulatory factor gene encodes a transcription factor USF that belongs to the proto-oncogene MYC family and is featured by a basic ...
,
PPRC1
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the ''PPRC1'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The mole ...
and
BRCA1
Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the ''BRCA1'' () gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. ''BRCA1'' is a ...
.
Regulation
The ''USF2'' gene is
repressed by the
microRNA
Micro ribonucleic acid (microRNA, miRNA, μRNA) are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. Found in plants, animals, and even some viruses, miRNAs are involved in RNA silencing and post-transcr ...
miR-10a.
References
Further reading
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External links
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