Regulator of nonsense transcripts 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''UPF2''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
This gene encodes a protein that is part of a post-splicing multiprotein complex, the
exon junction complex
An exon junction complex (EJC) is a protein complex which forms on a pre-messenger RNA strand at the junction of two exons which have been joined together during RNA splicing. The EJC has major influences on translation, surveillance, localization ...
, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.
UPF2 has recently been shown to alter adult behavior via alterations in hippocampal synaptic spine density and the late long-term potentiation of neurons.
Interactions
UPF2 has been shown to
interact with
UPF1
Regulator of nonsense transcripts 1 (or Up-frameshift suppressor 1 homolog) is a protein that in humans is encoded by the ''UPF1'' gene.
Function
This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junct ...
,
UPF3A
Regulator of nonsense transcripts 3A is a protein that in humans is encoded by the ''UPF3A'' gene.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The en ...
[ and UPF3B.]
References
Further reading
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{{PDB Gallery, geneid=26019