UM171 is a drug which acts as a small-molecule degrader of the enzyme

lysine-specific demethylase 1 Lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the ''KDM1A'' gene. LSD1 is a flavin-dependent monoamine oxidase, which can demethylate mono- and ...

(LSD1). It was originally discovered as an inducer of the proliferation of

hematopoietic stem cells Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis. In vertebrates, the first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within the ...

, a function which makes it useful for the treatment of various blood disorders. However more recently it has been found that suppression of LSD1 activity is also useful for the treatment of some forms of

cancer Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...

, and so UM171 is now being investigated for anti-cancer applications as well.

References

{{reflist Tetrazoles Cyclohexanes