The U1A polyadenylation inhibition element (PIE) is an
RNA element which is responsible for the regulation of the length of the
polyA tail
Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In euka ...
of the
U1A protein pre-mRNA. The PIE is located in the U1A mRNA
3' UTR
In molecular genetics, the three prime untranslated region (3′-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation (biology), translation termination codon. The 3′-UTR often contains regulatory regions that P ...
. PIE adopts a U-shaped structure, with binding sites for a single U1A protein at each bend and when complexed with the two proteins it blocks activity of
poly(A) polymerase (PAP), and inhibits its activity.
References
External links
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Cis-regulatory RNA elements
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