U.S. Highway 45
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U.S. Route 45 (US 45) is a major north-south
United States highway The United States Numbered Highway System (often called U.S. Routes or U.S. Highways) is an integrated network of roads and highways numbered within a nationwide grid in the contiguous United States. As the designation and numbering of these h ...
and a border-to-border route, from
Lake Superior Lake Superior is the largest freshwater lake in the world by surface areaThe Caspian Sea is the largest lake, but is saline, not freshwater. Lake Michigan–Huron has a larger combined surface area than Superior, but is normally considered tw ...
to the
Gulf of Mexico The Gulf of Mexico () is an oceanic basin and a marginal sea of the Atlantic Ocean, mostly surrounded by the North American continent. It is bounded on the northeast, north, and northwest by the Gulf Coast of the United States; on the southw ...
. A sign at the highway's northern terminus notes the total distance as . US 45 is notable for incorporating, in its maiden alignment, the first paved road in the South, a 49-mile (79 km) segment in
Lee County, Mississippi Lee County is a county in U.S. state of Mississippi. At the 2020 census, the population was 83,343. Its county seat is Tupelo. Lee County is included in the Tupelo Micropolitan Statistical Area. History Lee County was established by the Mi ...
. Let to contract in July 1914, the concrete highway opened on November 15, 1915. As of 2006, the highway's northern terminus is in
Ontonagon, Michigan Ontonagon ( ) is a village in the Upper Peninsula of the U.S. state of Michigan. The population was 1,285 at the 2020 census. It is the county seat of Ontonagon County, and is the only incorporated place within the county. The village is loca ...
, at the corner of Ontonagon and River Streets, a few blocks from
Lake Superior Lake Superior is the largest freshwater lake in the world by surface areaThe Caspian Sea is the largest lake, but is saline, not freshwater. Lake Michigan–Huron has a larger combined surface area than Superior, but is normally considered tw ...
( M-64 formerly terminated there as well until its rerouting in October 2006 to use the newly built Ontonagon River Bridge). US 45's southern terminus is in
Mobile, Alabama Mobile ( , ) is a city and the county seat of Mobile County, Alabama, United States. The population was 187,041 at the 2020 United States census, 2020 census. After a successful vote to annex areas west of the city limits in July 2023, Mobil ...
, at an intersection with
U.S. Route 98 U.S. Route 98 (US 98) is an east–west United States Highway in the Southeastern United States that runs from western Mississippi to southern Florida. It was established in 1933 as a route between Pensacola and Apalachicola, Florida, and has sin ...
.


Route description


Alabama

US 45 is concurrent with unsigned SR 17 between Mobile and Vinegar Bend, just north of Deer Park, in Washington County,
Alabama Alabama ( ) is a U.S. state, state in the Southeastern United States, Southeastern and Deep South, Deep Southern regions of the United States. It borders Tennessee to the north, Georgia (U.S. state), Georgia to the east, Florida and the Gu ...
. From Vinegar Bend to the
Mississippi Mississippi ( ) is a U.S. state, state in the Southeastern United States, Southeastern and Deep South regions of the United States. It borders Tennessee to the north, Alabama to the east, the Gulf of Mexico to the south, Louisiana to the s ...
state line, US 45 is concurrent with unsigned SR 57.


Mississippi

U.S. Highway 45 is part of a designated hurricane evacuation route in Mississippi. It is entirely four-laned from its point of entry from Alabama, at the town of State Line, to the Tennessee line just north of
Corinth Corinth ( ; , ) is a municipality in Corinthia in Greece. The successor to the ancient Corinth, ancient city of Corinth, it is a former municipality in Corinthia, Peloponnese (region), Peloponnese, which is located in south-central Greece. Sin ...
, along the way serving the towns of (from south to north) Waynesboro,
Meridian Meridian or a meridian line (from Latin ''meridies'' via Old French ''meridiane'', meaning “midday”) may refer to Science * Meridian (astronomy), imaginary circle in a plane perpendicular to the planes of the celestial equator and horizon * ...
,
Columbus Columbus is a Latinized version of the Italian surname "''Colombo''". It most commonly refers to: * Christopher Columbus (1451–1506), the Italian explorer * Columbus, Ohio, the capital city of the U.S. state of Ohio * Columbus, Georgia, a city i ...
and
Tupelo Tupelo commonly refers to: * Tupelo (tree), a small genus of deciduous trees with alternate, simple leaves * Tupelo, Mississippi, the county seat and the largest city of Lee County, Mississippi Tupelo may also refer to: Places * Tupelo, Arka ...
. U.S. 45 is a freeway in the vicinity of Meridian, from Shannon to Saltillo, and from south of Corinth to the Tennessee state line. At Brooksville, U.S. 45 splits away from U.S. 45 Alternate and serves the towns of
Columbus Columbus is a Latinized version of the Italian surname "''Colombo''". It most commonly refers to: * Christopher Columbus (1451–1506), the Italian explorer * Columbus, Ohio, the capital city of the U.S. state of Ohio * Columbus, Georgia, a city i ...
and
Aberdeen Aberdeen ( ; ; ) is a port city in North East Scotland, and is the List of towns and cities in Scotland by population, third most populous Cities of Scotland, Scottish city. Historically, Aberdeen was within the historic county of Aberdeensh ...
before rejoining U.S. 45 Alternate south of
Tupelo Tupelo commonly refers to: * Tupelo (tree), a small genus of deciduous trees with alternate, simple leaves * Tupelo, Mississippi, the county seat and the largest city of Lee County, Mississippi Tupelo may also refer to: Places * Tupelo, Arka ...
. The alternate roadway provides a more direct and entirely four-laned route between Meridian and Tupelo, bypassing Columbus to the west and, more closely, Starkville to the east. Major junctions of U.S. 45 in Mississippi include
U.S. Route 84 U.S. Route 84 (US 84) is an east–westUS 84 was signed north-south in parts of Colorado and New Mexico. United States Numbered Highway that started as a short Georgia–Alabama route in the original 1926 scheme. Later, in 1941, it h ...
at Waynesboro,
Interstate 20 Interstate 20 (I‑20) is a major east–west Interstate Highway in the Southern United States. I-20 runs beginning at an interchange with I-10 in Reeves County, Texas, and ending at an interchange with I-95 in Florence, South Carolina. B ...
/ 59 at Meridian,
U.S. Route 82 U.S. Route 82 (US 82) is an east–west United States highway in the Southern United States. Created on July 1, 1931 across central Mississippi and southern Arkansas, US 82 eventually became a route extending from the White Sands of New ...
at Columbus,
Interstate 22 Interstate 22 (I-22) is a Interstate Highway in the US states of Mississippi and Alabama, connecting I-269 near Byhalia, Mississippi, to I-65 near Birmingham, Alabama. I-22 is also Corridor X of the Appalachian Development Highway ...
/
U.S. Route 78 U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for from Swifton, Arkansas, to Charleston, South Carolina. From Byhalia, Mississippi to Graysville, Alabama, US 78 runs concurrently with Inte ...
at Tupelo and
U.S. Route 72 U.S. Route 72 (US 72) is an east–west United States highway that travels for from southwestern Tennessee, throughout North Mississippi, North Alabama, and southeastern Tennessee. The highway's western terminus is in Memphis, Tennessee a ...
at Corinth. Each of these junctions is an interchange and, with the exception of Columbus and Waynesboro, each is part of a freeway segment. The Mississippi section of U.S. 45 is defined at Mississippi Code Annotated § 65-3-3.


Tennessee

Southern section From the Mississippi state line, US 45 extends north past the cities of Guys, Eastview, Selmer, Bethel Springs,
Finger A finger is a prominent digit (anatomy), digit on the forelimbs of most tetrapod vertebrate animals, especially those with prehensile extremities (i.e. hands) such as humans and other primates. Most tetrapods have five digits (dactyly, pentadact ...
,
Henderson Henderson may refer to: People *Henderson (surname), description of the surname, and a list of people with the surname * Clan Henderson, a Scottish clan Places Argentina *Henderson, Buenos Aires Australia *Henderson, Western Australia Canada *H ...
, Pinson, and
Jackson Jackson may refer to: Places Australia * Jackson, Queensland, a town in the Maranoa Region * Jackson North, Queensland, a locality in the Maranoa Region * Jackson South, Queensland, a locality in the Maranoa Region * Jackson oil field in Durham, ...
to
Three Way ''Three Way'' is a 2004 neo-noir crime thriller film directed by Scott Ziehl and starring Dominic Purcell, Joy Bryant, Ali Larter, Desmond Harrington, Dwight Yoakam and Gina Gershon. The plot, based on Gil Brewer's pulp novel ''Wild To Possess'', ...
, where the highway splits into US 45W and US 45E. U.S. Route 45W US 45W is a state highway in
West Tennessee West Tennessee is one of the three Grand Divisions of Tennessee that roughly comprises the western quarter of the state. The region includes 21 counties between the Tennessee and Mississippi rivers, delineated by state law. Its geography consists ...
, connecting
Jackson Jackson may refer to: Places Australia * Jackson, Queensland, a town in the Maranoa Region * Jackson North, Queensland, a locality in the Maranoa Region * Jackson South, Queensland, a locality in the Maranoa Region * Jackson oil field in Durham, ...
with South Fulton via
Humboldt Humboldt may refer to: People * Alexander von Humboldt, German natural scientist, brother of Wilhelm von Humboldt * Wilhelm von Humboldt, German linguist, philosopher, and diplomat, brother of Alexander von Humboldt Fictional characters * Hu ...
, Trenton, Dyer, Rutherford, Kenton, and Union City. For the majority of its length, it is concurrent with unsigned State Route 5 (SR 5). U.S. Route 45E US 45E is a state highway in
West Tennessee West Tennessee is one of the three Grand Divisions of Tennessee that roughly comprises the western quarter of the state. The region includes 21 counties between the Tennessee and Mississippi rivers, delineated by state law. Its geography consists ...
, connecting
Jackson Jackson may refer to: Places Australia * Jackson, Queensland, a town in the Maranoa Region * Jackson North, Queensland, a locality in the Maranoa Region * Jackson South, Queensland, a locality in the Maranoa Region * Jackson oil field in Durham, ...
with South Fulton via
Medina Medina, officially al-Madinah al-Munawwarah (, ), also known as Taybah () and known in pre-Islamic times as Yathrib (), is the capital of Medina Province (Saudi Arabia), Medina Province in the Hejaz region of western Kingdom of Saudi Arabia, ...
,
Milan Milan ( , , ; ) is a city in northern Italy, regional capital of Lombardy, the largest city in Italy by urban area and the List of cities in Italy, second-most-populous city proper in Italy after Rome. The city proper has a population of nea ...
,
Bradford Bradford is a city status in the United Kingdom, city in West Yorkshire, England. It became a municipal borough in 1847, received a city charter in 1897 and, since the Local Government Act 1972, 1974 reform, the city status in the United Kingdo ...
,
Greenfield Greenfield or Greenfields may refer to: Places Canada * Greenfield, Edmonton, Alberta, a neighbourhood * Greenfield, Colchester County, Nova Scotia * Greenfield, Hants County, Nova Scotia * Greenfield, Kings County, Nova Scotia * Greenfield, Q ...
,
Sharon Sharon ( 'plain'), also spelled Saron, is a given name as well as a Hebrew name. In Anglosphere, English-speaking areas, Sharon is now predominantly a feminine given name, but historically it was also used as a masculine given name. In Israel, ...
, and
Martin Martin may refer to: Places Antarctica * Martin Peninsula, Marie Byrd Land * Port Martin, Adelie Land * Point Martin, South Orkney Islands Europe * Martin, Croatia, a village * Martin, Slovakia, a city * Martín del Río, Aragón, Spain * M ...
. For the majority of its length, it is concurrent with unsigned State Route 43 (SR 43) for most of the route's length except for short segments at Martin and South Fulton, where it is cosigned with SR 216 and SR 215 respectively. Northern section Mainline US 45, concurrent with unsigned SR 3, goes northeast and passes through neighborhoods in South Fulton along Chickasaw Drive before turning north onto Highland Drive at an intersection with
Kentucky Route 116 Kentucky (, ), officially the Commonwealth of Kentucky, is a landlocked state in the Southeastern region of the United States. It borders Illinois, Indiana, and Ohio to the north, West Virginia to the northeast, Virginia to the east, Tennes ...
(KY 116/W State Line Street) at the western edge of downtown. US 45 then crosses into
Kentucky Kentucky (, ), officially the Commonwealth of Kentucky, is a landlocked U.S. state, state in the Southeastern United States, Southeastern region of the United States. It borders Illinois, Indiana, and Ohio to the north, West Virginia to the ...
and the city of Fulton.


Kentucky

U.S. 45 enters Kentucky at Fulton then northeast past Mayfield then heads directly north into
Paducah Paducah ( ) is a home rule-class city in the Upland South, and the county seat of McCracken County, Kentucky, United States. The most populous city in the Jackson Purchase region, it is located in the Southeastern United States at the confluence ...
as a four-lane highway. In Paducah, U.S. 45 serves as a major artery, intersecting with
Interstate 24 Interstate 24 (I-24) is an Interstate Highway in the Midwestern and Southeastern United States. It runs diagonally from I-57, south of Marion, Illinois, to Chattanooga, Tennessee, at I-75. It travels through Illinois, Kentucky, Tennesse ...
at exit 7, and intersecting
US 60 U.S. Route 60 is a major east–west United States highway, traveling from southwestern Arizona to the Atlantic Ocean coast in Virginia. The highway's eastern terminus is in Virginia Beach, Virginia, where it is known as General Booth Bouleva ...
and 62. U.S. 45 leaves Kentucky from Paducah's northern border across the two-lane, metal-grate
Brookport Bridge The Brookport Bridge (officially the Paducah-Brookport Bridge 1929–43, and the Irvin S. Cobb Bridge since 1943) is a ten-span, steel deck (grate), narrow two-lane truss bridge that carries U.S. Route 45 (US 45) across the Ohio River ...
to
Brookport, Illinois Brookport is a city in Massac County, Illinois, United States. The population was 725 at the 2020 census, down from 984 in 2010. It is part of the Paducah, KY-IL Metropolitan Statistical Area. History Brookport was founded by Charles Pell ...
across the
Ohio River The Ohio River () is a river in the United States. It is located at the boundary of the Midwestern and Southern United States, flowing in a southwesterly direction from Pittsburgh, Pennsylvania, to its river mouth, mouth on the Mississippi Riv ...
.


Illinois

In the state of Illinois, U.S. 45 runs from a bridge across the Ohio River from
Paducah, Kentucky Paducah ( ) is a List of cities in Kentucky, home rule-class city in the Upland South, and the county seat of McCracken County, Kentucky, United States. The most populous city in the Jackson Purchase region, it is located in the Southeastern Unit ...
, through
Shawnee National Forest The Shawnee National Forest is a United States National Forest located in the Ozark and Shawnee Hills of Southern Illinois, United States. Administered by the U.S.D.A. Forest Service, it consists of approximately 498,615 acres (2,100 km²) ...
and north to the Wisconsin border east of
Antioch, Illinois Antioch is a village in Lake County, Illinois, United States. As of the 2020 United States census, 2020 census, the population was 14,622. The village is nestled into the Chain O'Lakes waterway system and borders the state of Wisconsin. Part of t ...
. With a length of in Illinois, U.S. 45 is the longest numbered route in Illinois. In its progress north from the Ohio River U.S. 45 first joins Interstate 24 as far as
Vienna Vienna ( ; ; ) is the capital city, capital, List of largest cities in Austria, most populous city, and one of Federal states of Austria, nine federal states of Austria. It is Austria's primate city, with just over two million inhabitants. ...
then heads northeast through
Harrisburg Harrisburg ( ; ) is the List of capitals in the United States, capital city of the Commonwealth (U.S. state), U.S. commonwealth of Pennsylvania and the county seat, seat of Dauphin County, Pennsylvania, Dauphin County. With a population of 50, ...
and Eldorado in Saline County and north through Fairfield,
Flora Flora (: floras or florae) is all the plant life present in a particular region or time, generally the naturally occurring (indigenous (ecology), indigenous) native plant, native plants. The corresponding term for animals is ''fauna'', and for f ...
, Effingham, Mattoon,
Champaign Champaign ( ) is a city in Champaign County, Illinois, United States. The population was 88,302 at the 2020 census. It is the tenth-most populous municipality in Illinois and the fourth most populous city in the state outside the Chicago metr ...
, Urbana, Gilman and Kankakee, then straight north through the western suburbs of Chicago in
Will County Will County is a county in the northeastern part of the state of Illinois. According to the 2020 census, it had a population of 696,355, an increase of 2.8% from 677,560 in 2010, making it Illinois's fourth-most populous county. The county sea ...
,
Cook County Cook County is the most populous county in the U.S. state of Illinois and the second-most-populous county in the United States, after Los Angeles County, California. More than 40 percent of all residents of Illinois live within Cook County. ...
and Lake County to the Wisconsin border.


Wisconsin

U.S. 45 enters the state in southeast
Wisconsin Wisconsin ( ) is a U.S. state, state in the Great Lakes region, Great Lakes region of the Upper Midwest of the United States. It borders Minnesota to the west, Iowa to the southwest, Illinois to the south, Lake Michigan to the east, Michig ...
. It runs concurrent with
Interstate 894 Interstate 894 (I-894) is a auxiliary Interstate Highway in Milwaukee County in the US state of Wisconsin. The route serves as a bypass of downtown Milwaukee, connecting with I-94 at the Zoo Interchange west of downtown and the Mitche ...
and
U.S. Route 41 U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula of Michigan. Until 1949, the part in southern Florida, from Naples to Miam ...
through the west side of metro
Milwaukee Milwaukee is the List of cities in Wisconsin, most populous city in the U.S. state of Wisconsin. Located on the western shore of Lake Michigan, it is the List of United States cities by population, 31st-most populous city in the United States ...
to form a major artery through the metropolitan area. It runs north to Fond du Lac. The highway routes near the western shore of
Lake Winnebago Lake Winnebago (, , ) is a shallow freshwater lake in the north central United States, located in east central Wisconsin. At , it is the largest lake entirely within the state, covering an area of about by with of shoreline, an average depth ...
through
Oshkosh, Wisconsin Oshkosh () is a city in Winnebago County, Wisconsin, United States, and its county seat. It is located on the western shore of Lake Winnebago and had a population of 66,816 as of the 2020 United States census, 2020 census, making it the List o ...
. U.S. 45 then travels north through
Wittenberg Wittenberg, officially Lutherstadt Wittenberg, is the fourth-largest town in the state of Saxony-Anhalt, in the Germany, Federal Republic of Germany. It is situated on the River Elbe, north of Leipzig and south-west of the reunified German ...
, Antigo, and Eagle River, as well as the state and national forests, until it leaves the state at
Land O' Lakes Land O'Lakes, Inc. is an American member-owned agricultural cooperative based in the Minneapolis-St. Paul suburb of Arden Hills, Minnesota, United States, focusing on the dairy industry. The cooperative has 1,959 direct producer-members, 751 me ...
and enters
Michigan Michigan ( ) is a peninsular U.S. state, state in the Great Lakes region, Great Lakes region of the Upper Midwest, Upper Midwestern United States. It shares water and land boundaries with Minnesota to the northwest, Wisconsin to the west, ...
.


Michigan

US 45 enters Michigan south of Watersmeet. From there, the highway crosses the Western
Upper Peninsula The Upper Peninsula of Michigan—also known as Upper Michigan or colloquially the U.P. or Yoop—is the northern and more elevated of the two major landmasses that make up the U.S. state of Michigan; it is separated from the Lower Peninsula b ...
through the
Ottawa National Forest The Ottawa National Forest is a national forest that covers in the Upper Peninsula of the U.S. state of Michigan. It includes much of Gogebic County, Michigan, Gogebic and Ontonagon County, Michigan, Ontonagon counties, as well as slices of Iro ...
running north to Ontonagon. US 45 ends just south of
Lake Superior Lake Superior is the largest freshwater lake in the world by surface areaThe Caspian Sea is the largest lake, but is saline, not freshwater. Lake Michigan–Huron has a larger combined surface area than Superior, but is normally considered tw ...
in downtown Ontonagon. The terminus was not changed in 2006 despite realignment then of M-38 and M-64 from the terminus to a crossing south.Bessert, Christopher J
Michigan Highways: Ontonagon State Trunkline Changes 2006
. URL accessed June 24, 2007.


History

Until March 1935, US 45's northern terminus was at US 12 in
Des Plaines, Illinois Des Plaines () is a city in Cook County, Illinois, United States. Per the 2020 United States census, 2020 census, the population was 60,675. The city is a suburb of Chicago and is located just north of O'Hare International Airport. It is situat ...
near
Chicago Chicago is the List of municipalities in Illinois, most populous city in the U.S. state of Illinois and in the Midwestern United States. With a population of 2,746,388, as of the 2020 United States census, 2020 census, it is the List of Unite ...
. Prior to the construction of the Interstate Highway system, US 45 was one of the main routes south out of Chicago toward
New Orleans New Orleans (commonly known as NOLA or The Big Easy among other nicknames) is a Consolidated city-county, consolidated city-parish located along the Mississippi River in the U.S. state of Louisiana. With a population of 383,997 at the 2020 ...
. Much of the traffic left US 45 at
Effingham, Illinois Effingham is a city in Effingham County, Illinois, United States, and its county seat. It is in South Central Illinois. Its population was 12,252 at the 2020 census. It is the principal city of the Effingham micropolitan statistical area. The ...
, continuing on through
Cairo, Illinois Cairo ( , sometimes ) is the southernmost city in the U.S. state of Illinois and the county seat of Alexander County, Illinois, Alexander County. A river city, Cairo has the lowest elevation of any location in Illinois and is the only Illinoi ...
along
Illinois Route 37 Illinois Route 37, Illinois 37 or IL 37, is a north–south state highway in southern Illinois. IL 37's southern terminus is at U.S. Route 51 (US 51) and IL 3 in Cairo and the northern terminus is at US 45 in Watson. Rou ...
.


Future

In 2023, an effort began to improve US 45 in
Tupelo, Mississippi Tupelo ( ) is a city in and the county seat of Lee County, Mississippi, United States. Founded in 1860, the population was 37,923 at the United States Census, 2020, 2020 census. It is the List of municipalities in Mississippi, 7th-most populous ...
. A $112 million plan to straighten US 45 at McCullough Boulevard, Hilda Avenue and Front Street in a series of interchanges to solve congestion and safety issues in this area. In additions to these improvements, Mississippi Senator
Roger Wicker Roger Frederick Wicker (born July 5, 1951) is an American politician, attorney, and United States Air Force, Air Force veteran serving as the Seniority in the United States Senate, senior United States Senate, United States senator from Mississi ...
requested $5 million for the 2023 fiscal year to fund preconstruction activities that would upgrade the existing substandard US 45 freeway to interstate standards between Tupelo and
Shannon, Mississippi Shannon is a town in Lee County, Mississippi. The population was 1,496 at the 2020 Census. Shannon is located on Mississippi Highway 145, west of U.S. Route 45. Chiwapa Creek flows south of the town. History The town is named for Samuel Shan ...
. The potential interstate spur, which would be an auxiliary route of I-22, is currently listed as High Priority Corridor 95.


Major intersections

;Southern segment :;Alabama :: in Mobile :: in Prichard :;Mississippi :: in Waynesboro :: in
Meridian Meridian or a meridian line (from Latin ''meridies'' via Old French ''meridiane'', meaning “midday”) may refer to Science * Meridian (astronomy), imaginary circle in a plane perpendicular to the planes of the celestial equator and horizon * ...
:: in Meridian :: west of
Columbus Columbus is a Latinized version of the Italian surname "''Colombo''". It most commonly refers to: * Christopher Columbus (1451–1506), the Italian explorer * Columbus, Ohio, the capital city of the U.S. state of Ohio * Columbus, Georgia, a city i ...
. The highways travel concurrently to Columbus. :: north-northwest of New Wren. The highways travel concurrently to the
Verona Verona ( ; ; or ) is a city on the Adige, River Adige in Veneto, Italy, with 255,131 inhabitants. It is one of the seven provincial capitals of the region, and is the largest city Comune, municipality in the region and in Northeast Italy, nor ...
Tupelo Tupelo commonly refers to: * Tupelo (tree), a small genus of deciduous trees with alternate, simple leaves * Tupelo, Mississippi, the county seat and the largest city of Lee County, Mississippi Tupelo may also refer to: Places * Tupelo, Arka ...
city line. :: in Tupelo :: in
Corinth Corinth ( ; , ) is a municipality in Corinthia in Greece. The successor to the ancient Corinth, ancient city of Corinth, it is a former municipality in Corinthia, Peloponnese (region), Peloponnese, which is located in south-central Greece. Sin ...
:;Tennessee :: in Selmer. The highways travel concurrently through the city. :: in
Jackson Jackson may refer to: Places Australia * Jackson, Queensland, a town in the Maranoa Region * Jackson North, Queensland, a locality in the Maranoa Region * Jackson South, Queensland, a locality in the Maranoa Region * Jackson oil field in Durham, ...
:: in
Three Way ''Three Way'' is a 2004 neo-noir crime thriller film directed by Scott Ziehl and starring Dominic Purcell, Joy Bryant, Ali Larter, Desmond Harrington, Dwight Yoakam and Gina Gershon. The plot, based on Gil Brewer's pulp novel ''Wild To Possess'', ...
:: in
Milan Milan ( , , ; ) is a city in northern Italy, regional capital of Lombardy, the largest city in Italy by urban area and the List of cities in Italy, second-most-populous city proper in Italy after Rome. The city proper has a population of nea ...
() :: in
Humboldt Humboldt may refer to: People * Alexander von Humboldt, German natural scientist, brother of Wilhelm von Humboldt * Wilhelm von Humboldt, German linguist, philosopher, and diplomat, brother of Alexander von Humboldt Fictional characters * Hu ...
() ;Northern segment :;Tennessee :: in South Fulton. US 45 / US 51 travel concurrently to
Fulton, Kentucky Fulton is a home rule-class city in Fulton County, Kentucky, United States. The population was 2,357 at the 2020 census, down from 2,445 at the 2010 census. It was once known as the "Banana Capital of the World", because 70% of imported ban ...
. :;Kentucky :: north of Mayfield :: in
Paducah Paducah ( ) is a home rule-class city in the Upland South, and the county seat of McCracken County, Kentucky, United States. The most populous city in the Jackson Purchase region, it is located in the Southeastern United States at the confluence ...
:: in Paducah. The highways travel concurrently through the city. :: in Paducah. US 45/US 60 travels concurrently through the city. :;Illinois :: in
Metropolis A metropolis () is a large city or conurbation which is a significant economic, political, and cultural area for a country or region, and an important hub for regional or international connections, commerce, and communications. A big city b ...
:: north-northeast of
Vienna Vienna ( ; ; ) is the capital city, capital, List of largest cities in Austria, most populous city, and one of Federal states of Austria, nine federal states of Austria. It is Austria's primate city, with just over two million inhabitants. ...
:: north of Mill Shoals :: east of
Flora Flora (: floras or florae) is all the plant life present in a particular region or time, generally the naturally occurring (indigenous (ecology), indigenous) native plant, native plants. The corresponding term for animals is ''fauna'', and for f ...
. The highways travel concurrently to northwest of Flora. :: in Effingham. The highways travel concurrently through the city. :: in Effingham :: northeast of Neoga :: in Mattoon :: in Tuscola Township :: in Pesotum :: in
Champaign Champaign ( ) is a city in Champaign County, Illinois, United States. The population was 88,302 at the 2020 census. It is the tenth-most populous municipality in Illinois and the fourth most populous city in the state outside the Chicago metr ...
. The highways travel concurrently to Urbana. :: in Urbana :: in Rantoul :: in Gilman. The highways travel concurrently through the city. :: east of Ashkum. The highways travel concurrently to Peotone Township. :: in Kankakee :: in Frankfort :: on the Mokena
Orland Park Orland Park is a village in Cook County, Illinois, United States, with a small portion in Will County. It is a suburb of Chicago. Per the 2020 census, Orland Park had a population of 58,703. Located 25 miles (40 km) southwest of Chicago, Or ...
Tinley Park Tinley Park is a village in Cook and Will counties in the U.S. state of Illinois. The population was 55,971 at the 2020 census. It is a suburb in the Chicago metropolitan area. History 19th century Modern settlement of the area now known as Ti ...
city line :: in Orland Park :: west of the
Palos Hills Palos Hills is a city in Cook County, Illinois, United States. It is a southwest suburb of Chicago. The city was established in 1958 and had reached a population of 18,530 in the 2020 census. It is named after Palos de la Frontera, Spain, from wh ...
Hickory Hills city line. US 12/US 45 travels concurrently to
Des Plaines Des Plaines () is a city in Cook County, Illinois, United States. Per the 2020 census, the population was 60,675. The city is a suburb of Chicago and is located just north of O'Hare International Airport. It is situated on and is named after t ...
. US 20/US 45 travels concurrently to the Stone ParkMelrose Park city line. :: in Willow Springs :: on the
Countryside In general, a rural area or a countryside is a geographic area that is located outside towns and cities. Typical rural areas have a low population density and small settlements. Agricultural areas and areas with forestry are typically describ ...
Hodgkins city line :: in La Grange :: on the WestchesterHillsideBellwood city line :: west of
Rosemont Rosemont may refer to: People Rosemont is a surname. Notable people with this surname include: * David A. Rosemont, American television producer * Franklin Rosemont (1943–2009), American poet, artist, historian * Norman Rosemont (1924–2018), ...
:: in Des Plaines :;Wisconsin :: in
Greenfield Greenfield or Greenfields may refer to: Places Canada * Greenfield, Edmonton, Alberta, a neighbourhood * Greenfield, Colchester County, Nova Scotia * Greenfield, Hants County, Nova Scotia * Greenfield, Kings County, Nova Scotia * Greenfield, Q ...
. The highways are concurrent for a 1/2 mile. :: in Greenfield. I-41 and US-41 stay concurrent until
Richfield Richfield may refer to: Places Canada *Richfield, Edmonton, Alberta, a neighbourhood * Richfield, Nova Scotia *Richfield, British Columbia, a ghost town from the Cariboo Gold Rush United States * Richfield, California *Richfield, Idaho * Richfiel ...
. I-894 stays concurrent to the
Milwaukee Milwaukee is the List of cities in Wisconsin, most populous city in the U.S. state of Wisconsin. Located on the western shore of Lake Michigan, it is the List of United States cities by population, 31st-most populous city in the United States ...
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Wauwatosa Wauwatosa ( ; colloquially Tosa) is a city in Milwaukee County, Wisconsin, United States. The population was 48,387 at the 2020 census. Wauwatosa is a suburb located immediately west of Milwaukee and is part of the Milwaukee metropolitan area. It ...
city line. :: in Milwaukee. :: in Wauwatosa. :: in the Town of Fond du Lac :: in Oshkosh :: in
Winchester Winchester (, ) is a City status in the United Kingdom, cathedral city in Hampshire, England. The city lies at the heart of the wider City of Winchester, a local government Districts of England, district, at the western end of the South Downs N ...
. The highways travel concurrently for 3 miles. :: in Monico. The highways travel concurrently through the town. :;Michigan :: in Watersmeet :: River Street/Chippewa Street in Ontonagon


See also

* U.S. Route 45 Business in Wittenburg, Wisconsin * U.S. Route 45 Business in
New London, Wisconsin New London is a city in Outagamie County, Wisconsin, Outagamie and Waupaca County, Wisconsin, Waupaca counties in the U.S. state of Wisconsin. Founded in 1851, the population was 7,348 at the 2020 census. The city has an annual Saint Patrick's D ...
* U.S. Route 45 Business in
Paducah, Kentucky Paducah ( ) is a List of cities in Kentucky, home rule-class city in the Upland South, and the county seat of McCracken County, Kentucky, United States. The most populous city in the Jackson Purchase region, it is located in the Southeastern Unit ...
* U.S. Route 45 Bypass in
Jackson, Tennessee Jackson is a city in and the county seat of Madison County, Tennessee, United States. Located east of Memphis, Tennessee, Memphis and 130 Miles Southwest of Nashville, it is a regional center of trade for West Tennessee. Its total population wa ...
*'' U.S. Route 45W Business'' in
Trenton, Tennessee Trenton is the county seat and fourth largest city of Gibson County, Tennessee, United States. As of the 2020 United States census, 2020 census, the population was 4,240. History Trenton was established in 1824 as a county seat for the newly cre ...
; decommissioned and re-signed as State Route 367 * U.S. Route 45W Business in
Humboldt, Tennessee Humboldt is a city in Gibson and Madison counties, Tennessee. The population was 8,452 at the 2010 census, a decline of 1,015 from 2000. It is the principal city of and is included in the Humboldt, Tennessee Micropolitan Statistical Area, whic ...
* U.S. Route 45E Business in
Martin, Tennessee Martin is a city in Weakley County, Tennessee, United States. The population was 10,825 according to the 2020 census. The city is the home of the University of Tennessee at Martin. History Martin is named for Captain William Martin. Willia ...
*'' U.S. Route 45 Business'' in
Tupelo, Mississippi Tupelo ( ) is a city in and the county seat of Lee County, Mississippi, United States. Founded in 1860, the population was 37,923 at the United States Census, 2020, 2020 census. It is the List of municipalities in Mississippi, 7th-most populous ...
*'' U.S. Route 45 Alternate'' in
Brooksville, Mississippi Brooksville is a town in Noxubee County, Mississippi, United States. The population was 1,223 at the 2010 census. The Sam D. Hamilton Noxubee National Wildlife Refuge is located west of the town, and the Black Prairie Wildlife Management Area ...
and
Shannon, Mississippi Shannon is a town in Lee County, Mississippi. The population was 1,496 at the 2020 Census. Shannon is located on Mississippi Highway 145, west of U.S. Route 45. Chiwapa Creek flows south of the town. History The town is named for Samuel Shan ...


References


External links


Endpoints of US 45
{{s-end 45 45