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Troponin C is a protein which is part of the troponin complex. It contains four calcium-binding EF hands, although different isoforms may have fewer than four functional calcium-binding subdomains. It is a component of thin filaments, along with
Troponin C is a protein which is part of the troponin complex. It contains four calcium-binding EF hands, although different isoforms may have fewer than four functional calcium-binding subdomains. It is a component of thin filaments, along with actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of ...
and tropomyosin. It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of troponin I (TnI). The C lobe can bind either Ca2+ or Mg2+. The N lobe, which binds only Ca2+, is the regulatory lobe and binds to the C domain of troponin I after calcium binding.
Isoforms
The tissue specific subtypes are: * Slow troponin C,TNNC1
Troponin C, also known as TN-C or TnC, is a protein that resides in the troponin complex on actin thin filaments of striated muscle (cardiac, fast-twitch skeletal, or slow-twitch skeletal) and is responsible for binding calcium in biology, calci ...
(3p21.1 )
* Fast troponin C, TNNC2 (20q12-q13.11, )
Mutations
Point mutations can occur in troponin C inducing alterations to Ca2+ and Mg2+ binding and protein structure, leading to abnormalities in muscle contraction. In cardiac muscle, they are related to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM). These known point mutations are: * A8V *D145E
D145E is a point mutation on troponin C that leads to hypertrophic cardiomyopathy disease. This mutation is caused by the change of nucleotide C to A at nucleotide 435, switching the amino acid aspartic acid to glutamic acid, which is located at th ...
* A31S
* C84Y
* E134D
* Y5H
* I148V
See also
* Troponin * Troponin T * Troponin I * Calcium-binding protein *Sliding filament model
Sliding may refer to:
* Sliding (dance), also floating or gliding, a group of footwork-oriented dance techniques
* Slide (baseball), an attempt by a baseball runner to avoid getting tagged out
* Sliding (motion)
See also
* Slide (disambiguation)
...
References
External links
* {{Calcium-binding proteins Troponin