Troleandomycin (TAO for short
) is a
macrolide antibiotic. It was sold in
Italy (branded Triocetin) and
Turkey (branded Tekmisin). It is no longer sold in Italy as of 2018.
The drug's
mode of action A mode of action (MoA) describes a functional or anatomical change, resulting from the exposure of a living organism to a substance. In comparison, a mechanism of action (MOA) describes such changes at the molecular level.
A mode of action is impor ...
is to bind to the ribosome, specifically in the tunnel through which the newly formed peptide egresses, thereby halting protein synthesis.
Troleandomycin is a
CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) () is an important enzyme in the body, mainly found in the liver and in the intestine. It oxidizes small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from t ...
inhibitor
Inhibitor or inhibition may refer to:
In biology
* Enzyme inhibitor, a substance that binds to an enzyme and decreases the enzyme's activity
* Reuptake inhibitor, a substance that increases neurotransmission by blocking the reuptake of a neurotra ...
that may cause
drug interactions.
References
CYP3A4 inhibitors
Macrolide antibiotics
Epoxides
Spiro compounds
Acetate esters
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