Trimethylsilylpropanoic acid (TMSP or TSP) is a chemical compound containing a

trimethylsilyl A trimethylsilyl group (abbreviated TMS) is a functional group in organic chemistry. This group consists of three methyl groups bonded to a silicon atom minus;Si(CH3)3 which is in turn bonded to the rest of a molecule. This structural group is c ...

group. It is used as internal reference in

nuclear magnetic resonance Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a ...

for aqueous solvents (e.g. D₂O). For that use it is often deuterated (3-(trimethylsilyl)-2,2,3,3-tetradeuteropropionic acid or TMSP-''d''₄). Other internal references that are frequently used in NMR experiments are DSS and

tetramethylsilane Tetramethylsilane (abbreviated as TMS) is the organosilicon compound with the formula Si(CH3)4. It is the simplest tetraorganosilane. Like all silanes, the TMS framework is tetrahedral. TMS is a building block in organometallic chemistry but also ...

References

Propionic acids Trimethylsilyl compounds Nuclear magnetic resonance {{NMR-stub