Trimerelysin I (, ''Trimeresurus metalloendopeptidase I'', ''hemorrhagic proteinase HR1A'', ''hemorrhagic metalloproteinase HR1A'', ''metalloproteinase HR1A'') is an

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

. This enzyme catalyses the following

chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...

: Cleavage of only two bonds His¹⁰-Leu and Ala¹⁴-Leu in the

insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabol ...

B chain This

endopeptidase Endopeptidase or endoproteinase are proteolytic peptidases that break peptide bonds of nonterminal amino acids (i.e. within the molecule), in contrast to exopeptidases, which break peptide bonds from end-pieces of terminal amino acids. For this r ...

is present in the venom of the habu snake (''

Trimeresurus flavoviridis The Okinawa habuU.S. Navy (1991). ''Poisonous Snakes of the World''. New York: US Government / Dover Publications Inc. 203 pp. . (''Protobothrops flavoviridis'') is a species of pit viper endemic to the Ryukyu Islands of Japan. No subspecies are ...

'').

References

External links

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