The enzyme triacylglycerol lipase (also triglyceride lipase, EC 3.1.1.3;systematic name triacylglycerol acylhydrolase) catalyses the hydrolysis of ester linkages of
triglycerides
A triglyceride (from ''wikt:tri-#Prefix, tri-'' and ''glyceride''; also TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids.
Triglycerides are the main constituents of body fat in humans and oth ...
:
:
triacylglycerol
A triglyceride (from ''tri-'' and '' glyceride''; also TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids.
Triglycerides are the main constituents of body fat in humans and other vertebrates as ...
+ H
2O
diacylglycerol
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. Two possible forms exist, 1,2-diacylglycerols and 1,3-diacylglycerols. Diglycerides are n ...
+ a
carboxylate
In organic chemistry, a carboxylate is the conjugate base of a carboxylic acid, (or ). It is an anion, an ion with negative charge.
Carboxylate salts are salts that have the general formula , where M is a metal and ''n'' is 1, 2,... ...
These lipases are widely distributed in animals, plants and prokaryotes. This family was also called class 3 lipases as they are only distantly related to other lipase families.
Human proteins containing this domain
DAGLA;
DAGLB;
LOC221955
LOC, L.O.C., Loc, LoC, or locs may refer to:
Places
* Lóc, a village in Sângeorgiu de Pădure, Mureș County, Romania
* Lócs, a village in Vas county, Hungary
* Line of Contact, meeting place of Western and Eastern Allied forces at the en ...
;
The
pancreatic
The pancreas (plural pancreases, or pancreata) is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine ...
enzyme acts only on an ester-water interface.
Nomenclature
Other names include ''lipase'', ''butyrinase'', ''tributyrinase'', ''Tween hydrolase'', ''steapsin'', ''triacetinase'', ''tributyrin esterase'', ''Tweenase'', ''amno N-AP'', ''Takedo 1969-4-9'', ''Meito MY 30'', ''Tweenesterase'', ''GA 56'', ''capalase L'', ''triglyceride hydrolase'', ''triolein hydrolase'', ''tween-hydrolyzing esterase'', ''amano CE'', ''cacordase'', ''triglyceridase'', ''triacylglycerol ester hydrolase'', ''amano P'', ''amano AP'', ''PPL'', ''glycerol-ester hydrolase'', ''GEH'', ''meito Sangyo OF lipase'', ''hepatic lipase'', ''lipazin'', ''post-heparin plasma protamine-resistant lipase'', ''salt-resistant post-heparin lipase'', ''heparin releasable hepatic lipase'', ''amano CES'', ''amano B'', ''tributyrase'', ''triglyceride lipase'', ''liver lipase'', ''hepatic monoacylglycerol acyltransferase'').
See also
*
Pancreatic lipase
Pancreatic lipases () are a protein family, family of lipolytic enzymes that hydrolyse ester linkages of triglycerides. Lipases are widely distributed in animals, plants and prokaryotes.
At least three tissue-specific isozymes exist in higher ...
*
Gastric lipase
Gastric lipase, also known as LIPF, is an enzymatic protein that, in humans, is encoded by the ''LIPF'' gene.
Function
Gastric lipase is an acidic lipase secreted by the gastric chief cells in the fundic mucosa in the stomach. It has a pH op ...
*
Lingual lipase
Lingual lipase is a member of a family of digestive enzymes called triacylglycerol lipases, EC 3.1.1.3, that use the catalytic triad of aspartate, histidine, and serine to hydrolyze medium and long-chain triglycerides into partial glycerides and ...
References
External links
*
{{InterPro content, IPR002921
EC 3.1.1
Protein domains
Protein families
Peripheral membrane proteins