Trifluoromescaline (TF-M) is a
derivative
In mathematics, the derivative is a fundamental tool that quantifies the sensitivity to change of a function's output with respect to its input. The derivative of a function of a single variable at a chosen input value, when it exists, is t ...
of the
phenethylamine
Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace ami ...
hallucinogen
Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mo ...
mescaline
Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, found ...
, which has a
trifluoromethoxy group replacing the central
methoxy
In organic chemistry, a methoxy group is the functional group consisting of a methyl group bound to oxygen. This alkoxy group has the formula .
On a benzene ring, the Hammett equation classifies a methoxy substituent at the ''para'' position a ...
group of mescaline. Trifluoromescaline was found to be one of the most potent compounds in the series, with a reported dosage of 15–40 mg (and 60 mg being described as a "strong overdose"), and a slow onset of action and long duration of effects, lasting 14–24 hours or more.
See also
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Substituted mescaline analogue
A substituted mescaline analogue, also known as a scaline and typically but not always a 4-substituted 3,5-dimethoxyphenethylamine, is an analogue of the phenethylamine serotonergic psychedelic mescaline (3,4,5-trimethoxyphenethylamine).
Other ...
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2C-TFM
2C-TFM, also known as 4-trifluoromethyl-2,5-dimethoxyphenethylamine, is a serotonin 5-HT2 receptor agonist and psychedelic drug of the phenethylamine and 2C families. It has also been called 2C-CF3, a name derived from the '' para''-trifluorom ...
*
2C-TFE
2C-TFE is a lesser-known psychedelic drug related to compounds such as 2C-E and 2C-TFM. It was first synthesised by Daniel Trachsel, and is reportedly a potent psychedelic with an active dose in the 5–15 mg range, and a long duration of ac ...
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2C-T-28
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2C-T-TFM
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3C-DFE
*
4-TM
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Allylescaline
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2-Bromomescaline
References
Psychedelic phenethylamines
Scalines
Serotonin receptor agonists
Trifluoromethyl ethers
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