Translin-associated protein X (abbr. TSNAX or TRAX) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''TSNAX''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
This gene encodes a protein which specifically interacts with
translin
Translin is a DNA-binding protein that in humans is encoded by the ''TSN'' gene. Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the pas ...
, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.
Both TSNAX and translin form the C3PO complex which facilitates endonucleolytic cleavage of the passenger strand during
microRNA
MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. m ...
loading into the RNA-induced silencing complex (RISC).
Interactions
TSNAX has been shown to
interact
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with
C1D
Nuclear nucleic acid-binding protein C1D is a protein that in humans is encoded by the ''C1D'' gene. The C1D protein is encoded by a DNA binding gene traced in the nucleus. Protein C1D has a chromosomal location of 2p14. C1D has a family of protei ...
.
References
Further reading
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External links
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Biology of bipolar disorder
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