Tom Misteli, Ph.D. is a Swiss-born (

Solothurn , neighboring_municipalities = Bellach, Biberist, Feldbrunnen-Sankt Niklaus, Langendorf, Rüttenen, Zuchwil , twintowns = Heilbronn (Germany), Kraków (Poland), Le Landeron (Switzerland) Solothurn ( , ; french: Soleure ; it, Soletta ; ...

) cell biologist and pioneer in the field of genome cell biology. Tom Misteli is best known for his work on elucidation of how genomes function in living cells. While a post-doc at the

Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, plant biology, genomics, and quantitative biology. It is one of 68 institutions supported by the Cancer Centers ...

, New York, United States, he developed methods to visualize proteins in the nucleus of living mammalian cells allowing for the first time to study gene expression in intact cells. His more recent work focuses on the role of genome organization and nuclear architecture on differentiation and disease. His cell biological elucidation of the mechanisms involved in the pre-mature aging disease

Hutchinson–Gilford progeria syndrome Progeria is a specific type of progeroid syndrome, also known as Hutchinson–Gilford syndrome. A single gene mutation is responsible for progeria. The gene, known as lamin A (LMNA), makes a protein necessary for holding the Nucleus of the cell ...

have revealed novel mechanisms of human

aging Ageing ( BE) or aging ( AE) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In ...

. He is an NIH Distinguished Investigator at the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. T ...

NIH The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1 ...

, Bethesda, MD, United States and the Director of the NCI Center for Cancer Research at the NIH. He was the Editor-in-Chief of

The Journal of Cell Biology The ''Journal of Cell Biology'' is a peer-reviewed scientific journal published by Rockefeller University Press. History In the early 1950s, a small group of biologists began to explore intracellular anatomy using the emerging technology of el ...

(2009-2015) and is the editor of Current Opinion in Cell Biology. He serves on the editorial boards of ''

Science Science is a systematic endeavor that Scientific method, builds and organizes knowledge in the form of Testability, testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earli ...

'', ''Cell'' and ''

PLOS Biology ''PLOS Biology'' is a monthly peer-reviewed scientific journal covering all aspects of biology. Publication began on October 13, 2003. It is the first journal published by the Public Library of Science. The editor-in-chief is Nonia Pariente. In ...

''. He co-authored the influential report by the US

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...

"Toward Precision Medicine". For his work he has won numerous awards including the Flemming Award, The Gold Medal of the Charles University, The Beerman Award, and the Feulgen Prize. He is an elected Fellow of the American Society for Cell Biology.

References

External links

*Misteli Lab

{{DEFAULTSORT:Misteli, Tom Cell biologists Living people Swiss biologists Year of birth missing (living people) People from Solothurn Fellows of the American Society for Cell Biology National Institutes of Health people 21st-century American biologists