Medical uses
Tolfenamic acid finds utility in the prevention and treatment of conditions associated with pain and inflammation. However, despite its efficacy when administered intramuscularly, subcutaneously, or orally, TFA-based drugs have not yet gained approval in the United States and some other countries due to the significant number of reported side effects.Chemistry
Tolfenamic acid, belonging to the pharmacological group of fenamates, possesses a chemical structure typical of anthranilic acid derivatives. In this structure, one of the hydrogen atoms of the nitro group is substituted by a benzene ring featuring a methyl group and a chlorine atom at the ortho- and meta- positions, respectively. Nine forms of tolfenamic acid have been identified, some of which are determined by conformational states. These polymorphic forms exhibit variations in the spatial arrangement within the unit cell and in the values of the C-N(H)-C-C angle. This diversity in solid forms makes TFA an attractive candidate for modification and utilization in medical applications.History
It was discovered by scientists at Medica Pharmaceutical Company inResearch
Tolfenamic acid demonstrates the ability to inhibit the growth of cancer cells in the pancreas, sigmoid colon, and rectum.References
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