Tirilazad is a drug that has been proposed to treat acute ischaemic

stroke Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemor ...

. When tested on animal models, tirilazad protects brain tissue, and reduces brain damage. However, the drug fails to treat, and even worsens a stroke when studied on a human being.

References

Aminopyrimidines Pregnanes 1-(2-Pyrimidinyl)piperazines 1-Pyrrolidinyl compounds {{nervous-system-drug-stub