Tinyatoxin (TTX or TTN) is an analog of the neurotoxin
resiniferatoxin. It occurs naturally in ''
Euphorbia poissonii''.
[''Euphorbia poissonii''](_blank)
in BoDD – Botanical Dermatology Database
It is a neurotoxin that acts via full agonism of the
vanilloid receptors of sensory nerves.
Tinyatoxin has a potential for pharmaceutical uses similar to uses of
capsaicin
Capsaicin (8-methyl-''N''-vanillyl-6-nonenamide) (, rarely ) is an active component of chili peppers, which are plants belonging to the genus ''Capsicum''. It is a potent Irritation, irritant for Mammal, mammals, including humans, and produces ...
. Tinyatoxin is about one third as strong as
resiniferatoxin but is still an ultrapotent analogue of capsaicin, with a heat intensity estimate of 300 to 350 times that of capsaicin.
References
Plant toxins
Terpenes and terpenoids
Carboxylate esters
Orthoesters
Ion channel toxins
Benzyl compounds
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