Thymidylate kinase (;
dTMP kinase
Thymidylate kinase (; dTMP kinase) catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:
: ATP + thymidine 5'-phosphate \rightleftharpoons ADP + thymidi ...
) catalyzes the
phosphorylation
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, ...
of
thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:
: ATP + thymidine 5'-phosphate
ADP + thymidine 5'-diphosphate
Thymidylate kinase is a ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis. The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in ''
Saccharomyces cerevisiae
''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have been o ...
''. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages.
Thymidylate kinase's subfamily is predicted thymidylate kinase, TKRP1.
Human protein
DTYMK
Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the ''DTYMK'' gene. and belongs to thymidylate kinase family of proteins.
References
Further reading
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contains this domain.
Structural studies
As of late 2007, 40
structures have been solved for this class of enzymes, with
PDB accession codes , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , and .
See also
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Thymidine kinase
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Thymidylate synthase
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Thymidine kinase in clinical chemistry
References
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{{DEFAULTSORT:Thymidylate Kinase
Protein families
EC 2.7.4
Enzymes of known structure