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Thiobarbital is a drug which is a
It is of note that although the drug can be prepared by the above route (cf e.g. thialbarbital), reaction of
barbiturate
Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid. They are effective when used medically as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological addiction potential as ...
derivative. It is the thiobarbiturate analogue of barbital
Barbital (or barbitone), marketed under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemic ...
.
Synthesis
It is of note that although the drug can be prepared by the above route (cf e.g. thialbarbital), reaction of barbital
Barbital (or barbitone), marketed under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemic ...
with phosphorus pentasulfide
Phosphorus pentasulfide is the inorganic compound with the formula ( monomer) or ( dimer). This yellow solid is the one of two phosphorus sulfides of commercial value. Samples often appear greenish-gray due to impurities. It is soluble in carb ...
constitutes an alternative route to thiobarbital.
References
Thiobarbiturates GABAA receptor positive allosteric modulators {{nervous-system-drug-stub