Thapelo is a unisex given name ''(meaning "prayer")'' of southern African origin that may refer to:
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Thapelo Ketlogetswe (born 1991), Botswana sprinter
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Thapelo Kotlhai (born 1989), South African music artist, tv and radio producer
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Thapelo Matsheka
Thapelo Matsheka is a Motswana politician and economist who served as the Minister of Finance and Economic Development from November 2019 to April 2021. He was elected as the Member of the National Assembly for Lobatse in October 2019. He is a m ...
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Thapelo Mogale, South African politician
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Thapelo Mokhele (born 1986), footballer from Lesotho
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Thapelo Mokoena (born 1982), South African actor and television presenter
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Thapelo Morena (born 1993), South African Footballer
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Thapelo Phora (born 1991), South African sprinter
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Thapelo Tale (born 1988), footballer from Lesotho
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Thapelo Tshilo (born 1985), South African footballer
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