Teva API is an international

pharmaceutical company The pharmaceutical industry is a Medicine, medical industry that discovers, develops, produces, and markets pharmaceutical goods such as medications and medical devices. Medications are then administered to (or Self-medicate, self-administered b ...

headquartered in

Israel Israel, officially the State of Israel, is a country in West Asia. It Borders of Israel, shares borders with Lebanon to the north, Syria to the north-east, Jordan to the east, Egypt to the south-west, and the Mediterranean Sea to the west. Isr ...

. Teva API is a stand-alone business unit of Teva Pharmaceutical Industries limited, the largest

generic drug A generic drug is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents. Generic drugs are allowed for sale after the patents on the original drugs expire. Because the active ch ...

manufacturer in the world and one of the 15 largest pharmaceutical companies worldwide. On top of supplying a major share of Teva's own needs, the Teva API division is an active competitor in world markets, investing both in the development of new products, manufacturing processes and in the upgrading of production facilities. In 2014, Teva API's sales to third parties totaled $724 million. In recent years growth occurred in all of Teva API's principal geographical markets:

North America North America is a continent in the Northern Hemisphere, Northern and Western Hemisphere, Western hemispheres. North America is bordered to the north by the Arctic Ocean, to the east by the Atlantic Ocean, to the southeast by South Ameri ...

Europe Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere. It is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, the Mediterranean Sea to the south, and Asia to the east ...

and International.

History

At the heart of the API division is the Israel-based Teva-Tech, formerly known as the Asia and Plantex plants which manufacture, develop and market raw materials for pharmaceuticals.

Acquisitions

Teva api has grown by acquiring manufacturing and development facilities around the world. Today, Teva api operates 21 plants and sales offices worldwide. Major Teva api's acquisitions: *2011 - Teva Acquisition of Theramex in Monaco * Teva api 2008 Acquisitions ** December 2008 – Teva Acquisition of Barr- Pliva in Croatia ** July 2008 – Teva Acquisition of Bentley in Spain ** April 2008 – Teva api Acquisition of Archimica in Puerto Rico * Acquisitions & Foundations since the 1990s ** 2006 – Acquisition of Wanma in China ** 2006 – Acquisition of Ivax Corporation ** 2004 – Acquisition of Sicor API in Italy, Mexico and Switzerland ** 2003 – Acquisition of RDL in India ** 2002 – Acquisition of PFC in Italy ** 1996 – Acquisition of BIOCRAFT in Missouri (US) ** 1995 – Foundation of TEVA-TECH in Israel ** 1995 – Acquisition of ICI in Italy & BIOGAL in Hungary ** 1991 – Acquisition of PROSINTEX in Italy

Facilities

Research and development

The R&D group at teva api consists of a team of over 760 top scientists located in 7 development centers worldwide: A large center in

(synthetic products and

peptide Peptides are short chains of amino acids linked by peptide bonds. A polypeptide is a longer, continuous, unbranched peptide chain. Polypeptides that have a molecular mass of 10,000 Da or more are called proteins. Chains of fewer than twenty am ...

s), a large center in

Hungary Hungary is a landlocked country in Central Europe. Spanning much of the Pannonian Basin, Carpathian Basin, it is bordered by Slovakia to the north, Ukraine to the northeast, Romania to the east and southeast, Serbia to the south, Croatia and ...

(

fermentation Fermentation is a type of anaerobic metabolism which harnesses the redox potential of the reactants to make adenosine triphosphate (ATP) and organic end products. Organic molecules, such as glucose or other sugars, are catabolized and reduce ...

and semi-synthetic products), and a facility in

India India, officially the Republic of India, is a country in South Asia. It is the List of countries and dependencies by area, seventh-largest country by area; the List of countries by population (United Nations), most populous country since ...

and additional sites in

Italy Italy, officially the Italian Republic, is a country in Southern Europe, Southern and Western Europe, Western Europe. It consists of Italian Peninsula, a peninsula that extends into the Mediterranean Sea, with the Alps on its northern land b ...

Croatia Croatia, officially the Republic of Croatia, is a country in Central Europe, Central and Southeast Europe, on the coast of the Adriatic Sea. It borders Slovenia to the northwest, Hungary to the northeast, Serbia to the east, Bosnia and Herze ...

Mexico Mexico, officially the United Mexican States, is a country in North America. It is the northernmost country in Latin America, and borders the United States to the north, and Guatemala and Belize to the southeast; while having maritime boundar ...

and the

Czech Republic The Czech Republic, also known as Czechia, and historically known as Bohemia, is a landlocked country in Central Europe. The country is bordered by Austria to the south, Germany to the west, Poland to the northeast, and Slovakia to the south ...

(development of high potency API). teva api's R&D focuses on the development of processes for the manufacturing of API, including intermediates, chemical and biological (fermentation), which are of interest to the generic drug industry, as well as Teva's proprietary drugs. The API R&D division also seeks methods to continuously reduce API production costs, enabling teva api to improve its cost structure.

Manufacturing and technology

Teva has 15 API production facilities located in Israel, Hungary, Italy, the U.S., the Czech Republic, India, Mexico, Puerto Rico, Monaco, China and Croatia. TAPI's holds expertise in a variety of production technologies, including

chemical synthesis Chemical synthesis (chemical combination) is the artificial execution of chemical reactions to obtain one or several products. This occurs by physical and chemical manipulations usually involving one or more reactions. In modern laboratory uses ...

, semi-synthetic fermentation, enzymatic synthesis, high potent manufacturing, plant extract technology, synthetic peptides,

vitamin D Vitamin D is a group of structurally related, fat-soluble compounds responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, along with numerous other biological functions. In humans, the most important compo ...

derivatives and

prostaglandin Prostaglandins (PG) are a group of physiology, physiologically active lipid compounds called eicosanoids that have diverse hormone-like effects in animals. Prostaglandins have been found in almost every Tissue (biology), tissue in humans and ot ...

s. Also, its advanced technology and expertise in the field of solid state particle technology enables it to meet specifications for particle size distribution (PSD),

bulk density In materials science, bulk density, also called apparent density, is a material property defined as the mass of the many particles of the material divided by the bulk volume. Bulk volume is defined as the total volume the particles occupy, includ ...

, specific surface area, polymorphism, as well as other characteristics. Teva's API facilities meet all applicable current

Good Manufacturing Practices Current good manufacturing practices (cGMP) are those conforming to the guidelines recommended by relevant agencies. Those agencies control the authorization and licensing of the manufacture and sale of food and beverages, cosmetics, pharmaceutic ...

(cGMP) requirements under U.S., European, Japanese, and other applicable quality standards. In some of the products that are sold in the U.S., TAPI utilizes controlled substances and therefore must meet the requirements of the

Controlled Substances Act The Controlled Substances Act (CSA) is the statute establishing federal government of the United States, federal drug policy of the United States, U.S. drug policy under which the manufacture, importation, possession, use, and distribution of ...

and the related regulations administered by the

Drug Enforcement Administration The Drug Enforcement Administration (DEA) is a Federal law enforcement in the United States, United States federal law enforcement agency under the U.S. Department of Justice tasked with combating illicit Illegal drug trade, drug trafficking a ...

Products

Teva api produces approximately 400

active pharmaceutical ingredient An active ingredient is any ingredient that provides biological activity, biologically active or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body of ...

s covering a wide range of products, including

respiratory The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies gr ...

cardiovascular In vertebrates, the circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the body. It includes the cardiovascular system, or vascular system, that consists of the heart a ...

, anti-cholesterol,

central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain, spinal cord and retina. The CNS is so named because the brain integrates the received information and coordinates and influences the activity o ...

, dermatological,

hormone A hormone (from the Ancient Greek, Greek participle , "setting in motion") is a class of cell signaling, signaling molecules in multicellular organisms that are sent to distant organs or tissues by complex biological processes to regulate physio ...

anti-inflammatory Anti-inflammatory is the property of a substance or treatment that reduces inflammation, fever or swelling. Anti-inflammatory drugs, also called anti-inflammatories, make up about half of analgesics. These drugs reduce pain by inhibiting mechan ...

oncology Oncology is a branch of medicine that deals with the study, treatment, diagnosis, and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's Etymology, etymological origin is the Greek word ὄγ ...

, immunosuppressants and

muscle relaxant A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therapeu ...

s. Its API

intellectual property Intellectual property (IP) is a category of property that includes intangible creations of the human intellect. There are many types of intellectual property, and some countries recognize more than others. The best-known types are patents, co ...

portfolio includes over 1,200 granted patents and pending applications worldwide.

References

{{Reflist, 2, refs= Pharmaceutical companies of Israel Science and technology in Israel Israeli brands Pharmaceutical companies established in 1935 Life sciences industry Companies based in Petah Tikva