Teofil Simchowicz (3 June 1879 – 31 December 1957) was a Polish neurologist who was born in

Ciechanowiec Ciechanowiec (; yi, טשעכֿאַנאָװיץ, german: Rudelstadt) is a small town in Gmina Ciechanowiec, Wysokie Mazowieckie County, Podlaskie Voivodeship, eastern Poland. As of December 2021, the town has a population of 4,511. History In the ...

near Warsaw, Poland. He studied medicine at the

Imperial University of Warsaw The University of Warsaw ( pl, Uniwersytet Warszawski, la, Universitas Varsoviensis) is a public university in Warsaw, Poland. Established in 1816, it is the largest institution of higher learning in the country offering 37 different fields of ...

, and received a medical degree in 1905. In years 1907-1910 he worked in Munich under Alois Alzheimer, studying neuropathological changes in dementia. During World War II he emigrated to

Palestine __NOTOC__ Palestine may refer to: * State of Palestine, a state in Western Asia * Palestine (region), a geographic region in Western Asia * Palestinian territories, territories occupied by Israel since 1967, namely the West Bank (including East ...

. He discovered

granulovacuolar degeneration Granulovacuolar degeneration refers to the occurrence within neurons of abnormal, fluid-filled bubbles (vacuoles) containing a dense proteinaceous granule. Granulovacuoles occur most commonly in pyramidal neurons of the hippocampus. They are present ...

(of Simchowicz), observed in hippocampal pyramidal cells in

Alzheimer's disease Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...

Bibliography

* Polski Słownik Biograficzny Tom XXXVII Warszawa-Kraków 1996–1997, s. 505-506 . Polish neurologists 19th-century Polish Jews 1879 births 1957 deaths {{poland-med-bio-stub