Tenilapine is an

atypical antipsychotic The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neurol ...

which has never been marketed in the US.

Pharmacodynamics

Tenilapine has a relatively high affinity for the 5-HT_2A receptor, and relatively low (micromolar) affinities for

dopamine receptor Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through diff ...

s. The ratio of D₂ to D₄ bonding is similar to that of

clozapine Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. It is used primarily to treat people with schizophrenia and schizoaffective disorder who have ...

. Like many other atypical antipsychotics, it is a potent 5-HT_2C antagonist.

References

{{Piperazines 4-Methylpiperazin-1-yl compounds 5-HT2A antagonists 5-HT2B antagonists Atypical antipsychotics Heterocyclic compounds with 3 rings M1 receptor antagonists M2 receptor antagonists M3 receptor antagonists M4 receptor antagonists M5 receptor antagonists Nitriles Thiophenes