Telenzepine is a
thienobenzodiazepine acting as selective
M1 antimuscarinic
A muscarinic acetylcholine receptor antagonist, also simply known as a muscarinic antagonist or as an antimuscarinic agent, is a type of anticholinergic drug that blocks the activity of the muscarinic acetylcholine receptors (mAChRs). The muscarin ...
. It is used in the treatment of peptic ulcers.
Telenzepine is
atropisomer
Atropisomers are stereoisomers arising because of hindered rotation about a covalent bond, single bond, where Gibbs free energy, energy differences due to steric strain or other contributors create a barrier to rotation that is high enough to all ...
ic, in other words the molecule has a stereogenic C–N-axis. In neutral aqueous solution it displays a half-life for racemization of the order of 1000 years. The enantiomers have been resolved. The activity is related to the (+)-isomer which is about 500-fold more active than the (–)-isomer at muscarinic receptors in the rat cerebral cortex.
See also
*
Pirenzepine
References
External links
*
4-Methylpiperazin-1-yl compounds
Carboxamides
Lactams
M1 receptor antagonists
Thienobenzodiazepines
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