Telapristone (), as telapristone acetate (proposed brand names Proellex, Progenta; former code name CDB-4124), is a
synthetic Synthetic things are composed of multiple parts, often with the implication that they are artificial. In particular, 'synthetic' may refer to:
Science
* Synthetic chemical or compound, produced by the process of chemical synthesis
* Synthetic o ...
,
steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and a ...
al
selective progesterone receptor modulator (SPRM) related to
mifepristone which is under development by Repros Therapeutics for the treatment of
breast cancer,
endometriosis
Endometriosis is a disease of the female reproductive system in which cells similar to those in the endometrium, the layer of tissue that normally covers the inside of the uterus, grow outside the uterus. Most often this is on the ovaries, f ...
, and
uterine fibroids.
It was originally developed by the
National Institutes of Health (NIH), and, as of 2017, is in
phase II Phase II, Phase 2 or Phase Two may refer to:
Media
* Marvel Cinematic Universe: Phase Two, six American superhero films from 2013–2015
* ''Star Trek: Phase II'', an unrealized television series based on the characters of Gene Roddenberry's ''S ...
clinical trials for the aforementioned indications.
In addition to its activity as an SPRM, the drug also has some
antiglucocorticoid activity.
See also
*
List of investigational sex-hormonal agents § Progestogenics
*
Aglepristone
*
Lilopristone
*
Onapristone
*
Toripristone
References
External links
Telapristone - AdisInsight
Acetate esters
Dimethylamino compounds
Antiglucocorticoids
Estranes
Ketones
Selective progesterone receptor modulators
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