Tegileridine is a drug which acts as a

μ-opioid receptor The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins. They are also referred to as μ(''mu'')-opioid peptide (MOP) receptors. The prototypical ...

agonist. It is closely related to compounds such as oliceridine, TRV734, and SHR9352, and shares a similar profile as a biased agonist selective for activation of the

G-protein G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their ...

signalling pathway over β-arrestin 2 recruitment. In January 2024, tegileridine was approved in China for the treatment of moderate to severe pain after abdominal surgery.

References

Mu-opioid receptor agonists 2-Pyridyl compounds Spiro compounds Oxygen heterocycles Secondary amines Ethoxy compounds Drugs developed by Jiangsu Hengrui {{analgesic-stub

See also

References