Teg49 is a non-coding RNA present in the extended

promoter region In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter. The RNA transcript may encode a protein (mRNA), or can have a function in and of i ...

of the staphylococcal accessory regulator ''sarA.'' It was identified by

RNA-seq RNA-Seq (named as an abbreviation of RNA sequencing) is a sequencing technique which uses next-generation sequencing (NGS) to reveal the presence and quantity of RNA in a biological sample at a given moment, analyzing the continuously changing c ...

and confirmed by

Northern blot The northern blot, or RNA blot,Gilbert, S. F. (2000) Developmental Biology, 6th Ed. Sunderland MA, Sinauer Associates. is a technique used in molecular biology research to study gene expression by detection of RNA (or isolated mRNA) in a sample.K ...

. It is modulated by ''sigB'' (''sarA'' regulator) and ''cshA'' (an ATP-dependant DEAD box

RNA helicase Helicases are a class of enzymes thought to be vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separating ...

) and it most likely contributes to virulence of '' S. aureus'' by modulating SarA expression.

References

Non-coding RNA {{molecular-cell-biology-stub