Tangeretin is an O-
polymethoxylated flavone that is found in
tangerine
The tangerine is a type of citrus fruit that is orange in colour, that is considered either a variety of the mandarin orange (''Citrus reticulata''), or a closely related species, under the name ''Citrus tangerina'', or yet as a hybrid (''Citr ...
and other
citrus
''Citrus'' is a genus of flowering trees and shrubs in the family Rutaceae. Plants in the genus produce citrus fruits, including important crops such as oranges, mandarins, lemons, grapefruits, pomelos, and limes.
''Citrus'' is nativ ...
peels. Tangeretin strengthens the cell wall and acts as a plant's defensive mechanism against disease-causing pathogens.
[Uckoo, RM; et al. Sep. Purif. Technol. 2011.]
It has also been used as a marker compound to detect contamination in citrus juices.
The following is a list of methods used to extract tangeretin from citrus peels:
* column chromatography
* preparative-high performance liquid chromatography
* super critical fluid chromatography
* high speed counter current chromatography
* a combination of vacuum flash silica gel chromatography and flash C
8 column chromatography
* flash chromatography
* isolation using ionic liquids and a cycle of centrifugation and decantation
[Mizuno, H.; Yoshikawa, H.; Usuki, T. Extraction of Nobiletin and Tangeretin From Peels of Shekwasha and Ponkan Using 2mim(MeO)(H)PO2] and Centrifugation. Natural Product Communications 2019, 14, 1-6.
]
The low solubility of Tangeretin is one of the main reasons for the low bioavailability of Tangeretin (and other flavonoids in general), and has been reported as a major challenge when using the compound in laboratory procedures.
[Panche, A. N.; Diwan, A. D.; Chandra, S. R. Flavonoids: an overview. Journal of Nutritional Science. 2016, 5, 47.
]
However, methods for tangeretin extraction are currently being tested to maximize efficiency and percent yields as its uses in treatment of cancer and other diseases are becoming better understood.
Tangeretin is commercially available as a dietary supplement. Tangeretin has also demonstrated beneficial applications in other pharmaceutical, nutraceutical, and cosmetic processes.
Tangeretin can be found as various synonyms throughout literature and research, including Tangeritin and 5,6,7,8,4’-pentamethoxyflavone (VIII).
References
{{flavone
O-methylated flavones
Flavonoids found in Rutaceae
4-Methoxyphenyl compounds