Talopram (Lu 3-010),
also known as phthalapromine, is a
selective norepinephrine reuptake inhibitor
A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epine ...
(NRI) which was researched for the management of
depression in the 1960s and 1970s but was never commercialized. Along with
talsupram, talopram is
structurally related to the
selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.
SSRIs increase the extracellul ...
(SSRI)
citalopram
Citalopram, sold under the brand name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive compulsive disorder, panic disorder, and soc ...
, as well as to
melitracen:
Synthesis
An unexpected/fortuitous rearrangement product in the synthesis of
litracen is what led to talopram.
[
]
See also
* Talsupram (tasulopram)
* Amedalin
* Daledalin
*, 1969 (#15).
*Original literature
* Prindamine (21489-22-5)
References
Antidepressants
Norepinephrine reuptake inhibitors
Isobenzofurans
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