Talopram (Lu 3-010),
also known as phthalapromine, is a
selective norepinephrine reuptake inhibitor
A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinep ...
(NRI) which was researched for the management of
depression in the 1960s and 1970s but was never commercialized. Along with
talsupram, talopram is
structurally
A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as ...
related to the
selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.
SSRIs primarily work by blo ...
(SSRI)
citalopram
Citalopram, sold under the brand name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive compulsive disorder, panic disorder, and soci ...
, as well as to
melitracen
Melitracen (brand names Melixeran, Trausabun) is a tricyclic antidepressant (TCA), for the treatment of depression and anxiety. In addition to single drug preparations, it is also available as Deanxit, marketed by Lundbeck, a combination produc ...
:
Synthesis
An unexpected/fortuitous rearrangement product in the synthesis of
litracen
Litracen (N-7,049) is a tricyclic antidepressant which was never marketed.
See also
* Fluotracen
* Melitracen
Melitracen (brand names Melixeran, Trausabun) is a tricyclic antidepressant (TCA), for the treatment of depression and anxiety. ...
is what led to talopram.
[
]
See also
* Talsupram (tasulopram)
* Amedalin
*Daledalin
Daledalin (UK-3557-15) is an antidepressant which was chemical synthesis, synthesized and clinical trial, trialed for clinical depression, depression in the early 1970s, but was never marketed. It is a binding selectivity, selective norepinephrin ...
*, 1969 (#15).
*Original literature
* Prindamine (21489-22-5)
References
Antidepressants
Norepinephrine reuptake inhibitors
Isobenzofurans
Abandoned drugs
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