Talopeptin is a chemical compound derived from cultures of ''
Streptomyces
''Streptomyces'' is the largest genus of Actinomycetota and the type genus of the family Streptomycetaceae. Over 500 species of ''Streptomyces'' bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, ...
''. It is a known reversible
inhibitor of
thermolysin
Thermolysin (, ''Bacillus thermoproteolyticus neutral proteinase'', ''thermoase'', ''thermoase Y10'', ''TLN'') is a thermostable neutral metalloproteinase enzyme produced by the Gram-positive bacteria ''Bacillus thermoproteolyticus''. It requires ...
and is expected to inhibit other
metalloproteinase
A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myoge ...
s.
Chemically, talopeptin differs from its closely related peptidase inhibitor
phosphoramidon
Phosphoramidon is a chemical compound derived from cultures of ''Streptomyces tanashiensis''. It is an enzyme inhibitor, inhibitor of the enzyme thermolysin, of the membrane metallo-endopeptidase,[MEROPS
MEROPS is an online database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors. The classification scheme for peptidases was published by Rawlings & Barrett in 1993, and that for protein inhibi ...]
online database for peptidases and their inhibitors
Talopeptin
Hydrolase inhibitors
Indoles
Phosphoramidates