Yttrium (⁹⁰Y) tacatuzumab tetraxetan (trade name AFP-Cide) is a

humanized monoclonal antibody Humanized antibodies are antibodies from non-human species whose protein sequences have been modified to increase their similarity to antibody variants produced naturally in humans. The process of "humanization" is usually applied to monoclonal a ...

intended for the treatment of cancer. The antibody itself, tacatuzumab, is conjugated with tetraxetan, a

chelator Chelation is a type of bonding of ions and molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central metal atom. These ligands are ...

for

yttrium-90 Yttrium-90 () is an isotope of yttrium. Yttrium-90 has found a wide range of uses in radiation therapy to treat some forms of cancer. Decay undergoes β− decay to zirconium-90 with a half-life of 64.1 hours and a decay energy of 2.28 ...

,WHO Drug Information
/ref> a

radioisotope A radionuclide (radioactive nuclide, radioisotope or radioactive isotope) is a nuclide that has excess nuclear energy, making it unstable. This excess energy can be used in one of three ways: emitted from the nucleus as gamma radiation; transferr ...

which destroys the tumour cells.

References

Monoclonal antibodies for tumors Antibody-drug conjugates Radiopharmaceuticals Yttrium compounds Experimental cancer drugs DOTA (chelator) derivatives {{antineoplastic-drug-stub