Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
encoding a protein of the same name.
Function
TRPs, mammalian homologs of the
Drosophila
''Drosophila'' (), from Ancient Greek δρόσος (''drósos''), meaning "dew", and φίλος (''phílos''), meaning "loving", is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or p ...
transient receptor potential
Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. Most of these are grouped into two broad groups: Group 1 includes TRPC ( "C" for canonical), TRP ...
(trp) protein, are
ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by Gating (electrophysiol ...
s that are thought to mediate capacitative calcium entry into the cell. TRPM7 is a protein that is both an ion channel and a
kinase
In biochemistry, a kinase () is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. This process is known as phosphorylation, where the high-energy ATP molecule don ...
. As a channel, it conducts calcium and monovalent cations to
depolarize cells and increase intracellular calcium. As a kinase, it is capable of
phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular
ATP and by the kinase mutants.
Interactions
TRPM7 has been shown to
interact with
PLCB1 and
PLCB2.
[
]
Clinical relevance
Patients with pathogenic variants in the TRPM7 gene suffer from hypomagnesemia, seizures and developmental delay.
See also
* TRPM
References
Further reading
*
*
*
External links
*
Ion channels
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