Tribbles homolog 2 is an atypical

protein kinase A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them ( phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a f ...

that is encoded in human by the ''TRIB2''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. TRIB2 is a

pseudokinase Pseudokinases are catalytically-deficient pseudoenzyme variants of protein kinases that are represented in all kinomes across the kingdoms of life. Pseudokinases have both physiological (signal transduction) and Pathophysiology, pathophysiological ...

member of the (

pseudoenzyme Pseudoenzymes are variants of enzymes that are catalytically-deficient (usually inactive), meaning that they perform little or no enzyme catalysis. They are believed to be represented in all major enzyme families in the kingdoms of life, where t ...

) class of signaling/scaffold proteins, possessing very low vestigial catalytic output in vitro and critical scaffolding signaling functions in cells. It is known to signal to canonical MAPK and AKT pathways and to regulate the ubiquitination of substrates with important functions in cell proliferation that control the cell ccyle. It has also been associated with various diseases, especially in human and murine blood and solid tumor models. Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target, and its three dimensional structure has been solved with the aid of stabilizing nanobodies corroborating the potential for new approaches for drug targeting outside the highly degraded ATP site and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation. Recent work has established a convincing link between targetable overexpression of TRIB2 and prostate cancer drug responses

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