TP53-regulating kinase, also known as PRPK is an
enzyme that in humans is encoded by the ''TP53RK''
gene.
This protein is a serine/threonine protein kinase that phosphorylates
p53 at Ser15.
PRPK is part of the KEOPS/EKC complex, which participates in transcription control,
telomere regulation
and tRNA modification.
Model organisms
Model organism
A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workin ...
s have been used in the study of TP53RK function. A conditional
knockout mouse line called ''Trp53rk
tm1a(EUCOMM)Wtsi'' was generated at the
Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized
phenotypic screen to determine the effects of deletion.
Additional screens performed: - In-depth immunological phenotyping
References
Further reading
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