Toll-like receptor 11 (TLR11) is a protein that in mice and rats is encoded by the gene ''TLR11'', whereas in humans it is represented by a
pseudogene
Pseudogenes are nonfunctional segments of DNA that resemble functional genes. Pseudogenes can be formed from both protein-coding genes and non-coding genes. In the case of protein-coding genes, most pseudogenes arise as superfluous copies of fun ...
. TLR11 belongs to the
toll-like receptor
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane protein, single-spanning receptor (biochemistry), receptors usually expressed on sentinel cells such as macrophages ...
(TLR) family and the interleukin-1 receptor/toll-like receptor superfamily and is found in the endosomes. In mice, TLR11 has been shown to recognise (bacterial)
flagellin
Flagellins are a family of proteins present in flagellated bacteria which arrange themselves in a hollow cylinder to form the filament in a bacterial flagellum. Flagellin has a mass on average of about 40,000 daltons. Flagellins are the princi ...
and (eukaryotic)
profilin present on certain microbes on, it helps propagate a host immune response. TLR11 plays a fundamental role in both the