Transcription factor II F (TF
IIF) is one of several
general transcription factors that make up the
RNA polymerase II
RNA polymerase II (RNAP II and Pol II) is a Protein complex, multiprotein complex that Transcription (biology), transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNA pol ...
preinitiation complex.
TF
IIF is encoded by the , , and genes.
TF
IIF binds to
RNA polymerase II
RNA polymerase II (RNAP II and Pol II) is a Protein complex, multiprotein complex that Transcription (biology), transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNA pol ...
when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the
promoter. Furthermore, TF
IIF stabilizes the RNA polymerase II while it's contacting
TBP and
TFIIB.
See also
*
TFIIA
*
TFIIB
*
TFIID
*
TFIIE
*
TFIIH
References
External links
*
Helicases
Molecular genetics
Proteins
Gene expression
Transcription factors
{{genetics-stub