Transcription elongation factor A protein 1 is a
protein that in humans is encoded by the ''TCEA1''
gene.
In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic
transcription preinitiation complex.
A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.
Interactions
TCEA1 has been shown to
interact with
GTF2H1 and
POLR2A.
References
Further reading
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