TAS2R14 agonist 28.1 (sometimes referred to simply as 28.1) is an experimental drug that acts as a potent and selective agonist of the
bitter taste
The gustatory system or sense of taste is the sensory system that is partially responsible for the perception of taste. Taste is the perception stimulated when a substance in the mouth reacts chemically with taste receptor cells located on tas ...
receptor
TAS2R14. It was developed by modification of
flufenamic acid, a pharmaceutical known for its bitter taste which produces bitterness via activation of TAS2R14, but is around six times more potent. TAS2R14 is also expressed in the lungs and causes
bronchodilatation, so TAS2R14 agonists such as 28.1 may be useful in the treatment of
asthma
Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wh ...
and other lung diseases.
See also
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Amarogentin
Amarogentin is a chemical compound found in gentian (''Gentiana lutea'') or in ''Swertia chirata''.
Gentian root has a long history of use as a herbal bitter in the treatment of digestive disorders and is an ingredient of many proprietary medic ...
*
Oligoporin D
Oligoporin D is a natural product isolated from the "bitter bracket" mushroom '' Amaropostia stiptica''. It was found to be one of the most potent agonists yet discovered for the bitter taste
The gustatory system or sense of taste is the sen ...
References
Experimental drugs
Pyrimidines
Tetrazoles
Anilines
Trifluoromethyl compounds
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