Transcriptional adapter 2-alpha is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''TADA2A''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.
Interactions
TADA2L has been shown to
interact with
GCN5L2
__NOTOC__
Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the ''KAT2A'' gene.
Interactions
GCN5L2 has been shown to interact with:
* DDB1,
* Ku70,
* Ku80
Ku80 is a protein that, in humans, is encoded by the ''XR ...
,
and
Myc.
References
Further reading
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{{PDB Gallery, geneid=6871