T1 Holin Family
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The Phage T1 Holin (T1 Holin) Family
TC# 1.E.37
is represented in enterobacterial phages T1, RTP and F20, ''
Klebsiella ''Klebsiella'' is a genus of Gram-negative, oxidase-negative, rod-shaped bacteria with a prominent polysaccharide-based capsule. ''Klebsiella'' is named after German-Swiss microbiologist Edwin Klebs (1834–1913). Carl Friedlander described ' ...
'' phage KP36, and ''
Escherichia ''Escherichia'' ( ) is a genus of Gram-negative, non-Endospore, spore-forming, Facultative anaerobic organism, facultatively anaerobic, rod-shaped bacteria from the family Enterobacteriaceae. In those species which are inhabitants of the gastroin ...
'' phage ADB-2. All of these possess a putative holin that share a high level of identity. Additionally, Gp9 of ''
E. coli ''Escherichia coli'' ( )Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. is a gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escherichia'' that is commonly foun ...
'' phage phiE49 is similar in sequence. These proteins are short, 55 to 71 amino acyl residues (aas) in length, and exhibit a single transmembrane segment (TMS). A representative list of proteins belonging to the T1 Holin family can be found in th
Transporter Classification Database


See also

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Holin Holins are a diverse group of small proteins produced by dsDNA bacteriophages in order to trigger and control the degradation of the host's cell wall at the end of the lytic cycle. Holins form pores in the host's cell membrane, allowing lysins t ...
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Lysin Lysins, also known as endolysins or murein hydrolases, are hydrolase, hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able ...
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Transporter Classification Database The Transporter Classification Database (or TCDB) is an International Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system for membrane transport proteins, including ion channels. Classification The upper level of cla ...


Further reading

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References

{{CCBYSASource, sourcepath=http://tcdb.org/search/result.php?tc=1.E.37, sourcearticle=The Phage T1 Holin (T1 Holin) Family, revision=699838558 Protein families Membrane proteins Transmembrane proteins Transmembrane transporters Transport proteins Integral membrane proteins Holins