CD3e molecule, epsilon also known as CD3E is a
polypeptide
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides ...
which in humans is encoded by the ''CD3E''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
which resides on chromosome 11.
Function
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-
gamma, -
delta
Delta commonly refers to:
* Delta (letter) (Δ or δ), a letter of the Greek alphabet
* River delta, at a river mouth
* D (NATO phonetic alphabet: "Delta")
* Delta Air Lines, US
* Delta variant of SARS-CoV-2 that causes COVID-19
Delta may also r ...
and -
zeta
Zeta (, ; uppercase Ζ, lowercase ζ; grc, ζῆτα, el, ζήτα, label=Demotic Greek, classical or ''zē̂ta''; ''zíta'') is the sixth letter of the Greek alphabet. In the system of Greek numerals, it has a value of 7. It was derived fr ...
, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the
T cell receptor
The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The bindin ...
-
CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.
Clinical significance
Defects in this gene cause severe
immunodeficiency
Immunodeficiency, also known as immunocompromisation, is a state in which the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent. Most cases are acquired ("secondary") due to extrinsic factors that a ...
.
This gene has also been linked to a susceptibility to type I diabetes in women.
Interactions
T-cell surface glycoprotein CD3 epsilon chain has been shown to
interact
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with
TOP2B
DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the ''TOP2B'' gene.
Function
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is ...
,
and
NCK2.
See also
*
CD3 (immunology)
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. I ...
*
Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophen ...
References
Further reading
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{{NLM content
Clusters of differentiation