Protein kinase C and casein kinase substrate in neurons protein 1 also known as syndapin I is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''PACSIN1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Interactions
PACSIN1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with GTPases of the Dynamin family (Dynamin 1, 2 and 3). Based on this interaction, its localization and functional role the protein was named syndapin I (synaptic dynamin-associated protein I).
A variety of interactions have been published:
*
DNM1
Dynamin-1 is a protein that in humans is encoded by the ''DNM1'' gene.
Function
Dynamin possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular ...
*
Huntingtin
Huntingtin (Htt) is the protein coded for in humans by the ''HTT'' gene, also known as the ''IT15'' ("interesting transcript 15") gene. Mutation, Mutated ''HTT'' is the cause of Huntington's disease (HD), and has been investigated for this role an ...
*
PACSIN2
Protein kinase C and casein kinase substrate in neurons protein 2 (Pacsin 2) is a protein that in humans is encoded by the ''PACSIN2'' gene. Pacsin 2 is involved in the formation of caveolae.
The variant rs2413739 in PACSIN2 has been associated w ...
[
]
References
Further reading
*
*
External links
PDBe-KB
provides an overview of all the structure information available in the PDB for Human Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)
{{Gene-6-stub