Symphytum Longisetum
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''Symphytum'' is a
genus Genus (; : genera ) is a taxonomic rank above species and below family (taxonomy), family as used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In bino ...
of flowering plants in the borage family,
Boraginaceae Boraginaceae, the Borago, borage or forget-me-not family, includes about 2,000 species of shrubs, trees, and herbs in 146 to 154 genus, genera with a worldwide distribution. The APG IV system from 2016 classifies the Boraginaceae as single famil ...
, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient
traditional medicine Traditional medicine (also known as indigenous medicine or folk medicine) refers to the knowledge, skills, and practices rooted in the cultural beliefs of various societies, especially Indigenous groups, used for maintaining health and treatin ...
). ''Symphytum'' is native to northern temperate regions of Asia and North America, with a wide introduced distribution on both continents. There are 59 recognized species. Some species and hybrids, particularly '' S. officinale'', '' Symphytum grandiflorum'', and ''S.'' × ''uplandicum'', are used in
gardening Gardening is the process of growing plants for their vegetables, fruits, flowers, herbs, and appearances within a designated space. Gardens fulfill a wide assortment of purposes, notably the production of Aesthetics, aesthetically pleasing area ...
and
herbal medicine Herbal medicine (also called herbalism, phytomedicine or phytotherapy) is the study of pharmacognosy and the use of medicinal plants, which are a basis of traditional medicine. Scientific evidence for the effectiveness of many herbal treatments ...
. Species in the genus ''Symphytum'' are different from '' Andersonglossum virginianum'', known as wild comfrey, which is another member of the borage family.


Species

27 species are accepted. *''
Symphytum aintabicum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum anatolicum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *'' Symphytum asperum'' – prickly comfrey, rough comfrey *''
Symphytum × bicknellii ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum bornmuelleri ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum brachycalyx ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' – Palestine comfrey *'' Symphytum bulbosum'' – bulbous comfrey *''
Symphytum carpaticum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum caucasicum ''Symphytum caucasicum'', the beinwell, blue comfrey, or Caucasian comfrey, is an ornamental plant of genus ''Symphytum'' in the family Boraginaceae, which is native to the Caucasus The Caucasus () or Caucasia (), is a region spanning East ...
'' – Caucasian comfrey *''
Symphytum circinale ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum cordatum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum creticum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum davisii ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum × ferrariense ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *'' Symphytum grandiflorum'' – creeping comfrey *''
Symphytum gussonei ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum hajastanum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum ibiricum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' – Iberian comfrey *''
Symphytum kurdicum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *''
Symphytum longisetum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *'' Symphytum × mosquense'' *''
Symphytum officinale ''Symphytum officinale'' is a perennial flowering plant in the family Boraginaceae. Along with thirty four other species of ''Symphytum'', it is known as comfrey (from the Latin confervere to 'heal' or literally to 'boil together', referring to u ...
'' – comfrey *'' Symphytum orientale'' – white comfrey *'' Symphytum ottomanum'' *''
Symphytum podcumicum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *'' Symphytum pseudobulbosum'' *'' Symphytum savvalense'' *''
Symphytum sylvaticum ''Symphytum'' is a genus of flowering plants in the borage family, Boraginaceae, known by the common name comfrey (pronounced , from the Latin confervere to 'heal' or literally to 'boil together', referring to uses in ancient traditional medicin ...
'' *'' Symphytum tauricum'' – Crimean comfrey *''
Symphytum tuberosum ''Symphytum tuberosum'', the tuberous comfrey, is a species of ''Symphytum'' in the family Boraginaceae. Species characteristics Tuberous comfrey flowers from April to June, however it also reproduces asexually, that is vegetatively, having ...
'' – tuberous comfrey *'' Symphytum × ullepitschii'' *'' Symphytum × uplandicum'' (''S. asperum'' × ''S. officinale'', synonym: ''S. peregrinum'') – Russian comfrey, healing herb, blackwort, bruisewort, wallwort, gum plant *'' Symphytum × wettsteinii''


Cultivation

The Russian comfrey 'Bocking 4' and 'Bocking 14' cultivars were developed during the 1950s by Lawrence D. Hills, the founder of the
Henry Doubleday Research Association Garden Organic, formerly known as the Henry Doubleday Research Association (HDRA), is a UK organic growing charity dedicated to researching and promoting organic gardening, farming and food. The charity maintains the Heritage Seed Library to pres ...
(the
organic gardening Organic horticulture is the science and art of growing fruits, vegetables, flowers, or ornamental plants by following the essential principles of organic agriculture in soil building and conservation, pest management, and heirloom variety pres ...
organization itself named after Henry Doubleday, who first introduced Russian comfrey into Britain in the nineteenth century) following trials at
Bocking, Essex Bocking is a suburban village on the northern side of Braintree, Essex, Braintree, in Essex, England. Bocking village was historically in two parts; the original settlement around the parish church became known as Bocking Churchstreet, while a ...
.


Propagation

Bocking 4 and 14 are sterile, and therefore will not set seed (one of its advantages over other cultivars as it will not spread out of control); thus, it is propagated from root cuttings. The gardener can produce "offsets" from mature, strongly growing plants by driving a spade horizontally through the leaf clumps about below the soil surface. This removes the crown, which can then be split into pieces. The original plant will quickly recover, and each piece can be replanted with the growing points just below the soil surface, and will quickly grow into new plants. Offsets can also be purchased by mail order from specialist nurseries in order to initially build up a stock of plants.


Phytochemistry, folk medicine, and toxicity

Folk medicine Traditional medicine (also known as indigenous medicine or folk medicine) refers to the knowledge, skills, and practices rooted in the cultural beliefs of various societies, especially Indigenous groups, used for maintaining health and treatin ...
names for comfrey include knitbone, boneset, and the derivation of its Latin name ''Symphytum'' (from the Greek ''symphytis'', meaning growing together of bones, and ''phyton'', a plant, referring to its ancient uses. Similarly, the common French name is , meaning to weld together. The tradition in different cultures and languages suggest a common belief in its usefulness for mending bones. Comfrey contains mixed
phytochemical Phytochemicals are naturally-occurring chemicals present in or extracted from plants. Some phytochemicals are nutrients for the plant, while others are metabolites produced to enhance plant survivability and reproduction. The fields of ext ...
s in varying amounts, including
allantoin Allantoin is a chemical compound with formula C4H6N4O3. It is also called 5-ureidohydantoin or glyoxyldiureide. It is a diureide of glyoxylic acid. Allantoin is a major metabolic intermediate in most organisms including animals, plants and bacter ...
,
mucilage Mucilage is a thick gluey substance produced by nearly all plants and some microorganisms. These microorganisms include protists which use it for their locomotion, with the direction of their movement always opposite to that of the secretion of ...
,
saponin Saponins (Latin ''sapon'', 'soap' + ''-in'', 'one of') are bitter-tasting, usually toxic plant-derived secondary metabolites. They are organic chemicals that become foamy when agitated in water and have high molecular weight. They are present ...
s,
tannin Tannins (or tannoids) are a class of astringent, polyphenolic biomolecules that bind to and Precipitation (chemistry), precipitate proteins and various other organic compounds including amino acids and alkaloids. The term ''tannin'' is widel ...
s,
pyrrolizidine alkaloid Pyrrolizidine alkaloids (PAs), sometimes referred to as necine bases, are a group of naturally occurring alkaloids based on the structure of pyrrolizidine. Their use dates back centuries and is intertwined with the discovery, understanding, and e ...
s, and
inulin Inulins are a group of naturally occurring polysaccharides produced by many types of plants, industrially most often extracted from chicory. The inulins belong to a class of dietary fibers known as fructans. Inulin is used by some plants as a ...
, among others. Pyrrolizidine alkaloids are responsible for comfrey's
liver toxicity Hepatotoxicity (from ''hepatic toxicity'') implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdr ...
, which is associated with consuming this plant or its
extract An extract (essence) is a substance made by extracting a part of a raw material, often by using a solvent such as ethanol, oil or water. Extracts may be sold as tinctures or absolutes or dried and powdered. The aromatic principles of ma ...
s. In modern
herbalism Herbal medicine (also called herbalism, phytomedicine or phytotherapy) is the study of pharmacognosy and the use of medicinal plants, which are a basis of traditional medicine. Scientific evidence for the effectiveness of many herbal treatments ...
, comfrey is most commonly used topically. In 2001, the United States
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
issued a ban of comfrey products marketed for internal use, and a warning label for those intended for external use. Use of comfrey is particularly discouraged during pregnancy and lactation, in infants, and in people with liver, kidney, or
vascular Vascular can refer to: * blood vessels, the vascular system in animals * vascular tissue Vascular tissue is a complex transporting tissue, formed of more than one cell type, found in vascular plants. The primary components of vascular tissue ...
diseases.


References

{{Authority control Boraginaceae genera Taxa named by Carl Linnaeus