Suzanne Cory (born 11 March 1942) is an Australian molecular biologist. She has worked on the genetics of the immune system and cancer and has lobbied her country to invest in science. She is married to fellow scientist Jerry Adams, also a WEHI scientist.

Early life and education

Suzanne Cory was raised in the

Kew Kew () is a district in the London Borough of Richmond upon Thames. Its population at the 2011 census was 11,436. Kew is the location of the Royal Botanic Gardens ("Kew Gardens"), now a World Heritage Site, which includes Kew Palace. Kew is ...

suburbs of

Melbourne Melbourne ( , ; Boonwurrung language, Boonwurrung/ or ) is the List of Australian capital cities, capital and List of cities in Australia by population, most populous city of the States and territories of Australia, Australian state of Victori ...

Australia Australia, officially the Commonwealth of Australia, is a country comprising mainland Australia, the mainland of the Australia (continent), Australian continent, the island of Tasmania and list of islands of Australia, numerous smaller isl ...

. She was educated at Canterbury Girls' Secondary College and University High School, Melbourne. Cory studied at the

University of Melbourne The University of Melbourne (colloquially known as Melbourne University) is a public university, public research university located in Melbourne, Australia. Founded in 1853, it is Australia's second oldest university and the oldest in the state ...

where she graduated with a BSc degree in 1964 and an MSc degree in 1965, both in

Biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

. In 1966, she then went to the

MRC Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

(LMB) in

Cambridge Cambridge ( ) is a List of cities in the United Kingdom, city and non-metropolitan district in the county of Cambridgeshire, England. It is the county town of Cambridgeshire and is located on the River Cam, north of London. As of the 2021 Unit ...

England England is a Countries of the United Kingdom, country that is part of the United Kingdom. It is located on the island of Great Britain, of which it covers about 62%, and List of islands of England, more than 100 smaller adjacent islands. It ...

and obtained a

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

Molecular Biology Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...

from the

University of Cambridge The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...

in 1968.

Career and research

Cory travelled to the

University of Geneva The University of Geneva (French: ''Université de Genève'') is a public university, public research university located in Geneva, Switzerland. It was founded in 1559 by French theologian John Calvin as a Theology, theological seminary. It rema ...

for her post-doctoral studies. While in Geneva, she focused on sequencing the RNA of R17

bacteriophage A bacteriophage (), also known informally as a phage (), is a virus that infects and replicates within bacteria. The term is derived . Bacteriophages are composed of proteins that Capsid, encapsulate a DNA or RNA genome, and may have structu ...

for the purpose of using it as a model. In 1971, Cory and her husband began their research at the

Walter and Eliza Hall Institute of Medical Research Walter may refer to: People and fictional characters * Walter (name), including a list of people and fictional and mythical characters with the given name or surname * Little Walter, American blues harmonica player Marion Walter Jacobs (1930–1 ...

, located in Melbourne, Australia. The two scientists helped introduce new scientific technology and methods they had been exposed to in Geneva and Cambridge, which helped expand and better the molecular biology research in Australia. They initially chose to study the genetic component of immunity, discovering that

antibody An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as pathogenic bacteria, bacteria and viruses, includin ...

genes are a combination of pieces and can be arranged in a variety of ways. This discovery helped explain the diversity of the immune system and its ability to fight a large array of harmful cell invaders. After a decade of studying the immune system, Cory's lab switched their focus to

cancer Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...

and the genetic components of various cancers. Her lab discovered the genetic mutations that lead to

Burkitt's lymphoma Burkitt's lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, the Irish surgeon who first described the disease in 1958 while working in equatorial Africa ...

and

Follicular lymphoma Follicular lymphoma (FL) is a cancer that involves certain types of white blood cells known as lymphocytes. This cancer is a form of Non-Hodgkin Lymphoma and it originates from the uncontrolled division of specific types of B-cells ( centrocytes ...

. One of the main focuses of their cancer cell research is on cell proliferation and cell death. In particular, the oncoprotein

Myc ''Myc'' is a family of regulator genes and proto-oncogenes that code for transcription factors. The ''Myc'' family consists of three related human genes: ''c-myc'' ( MYC), ''l-myc'' ( MYCL), and ''n-myc'' ( MYCN). ''c-myc'' (also sometimes r ...

and the

Bcl-2 Bcl-2, encoded in humans by the ''BCL2'' gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) while other BCL2 family members can either inhibit or induce it. It was the first a ...

protein family are of interest to her current research lab. Bcl-2 is an important family of intracellular proteins that helps regulate

apoptosis Apoptosis (from ) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemistry, Biochemical events lead to characteristic cell changes (Morphology (biol ...

, or cell suicide. Bcl-2, paired with other regulators, prevents

caspase Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death. They are named caspases due to their specific cyste ...

s from being activated. The caspases, a type of protease, remain inactive until signaled through a cascade to degrade the proteins that make up a cell. Cory's lab has developed Bcl2-blocking agents called BH3 mimetics, which, when paired with low-dose

chemotherapy Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (list of chemotherapeutic agents, chemotherapeutic agents or alkylating agents) in a standard chemotherapy re ...

, have had positive results treating specific types of aggressive

lymphoma Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). The name typically refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enlarged lymph node ...

s. Cory is the immediate past President of the

Australian Academy of Science The Australian Academy of Science was founded in 1954 by a group of distinguished Australians, including Australian Fellows of the Royal Society of London. The first president was Sir Mark Oliphant. The academy is modelled after the Royal Soci ...

. She was the first-elected woman President of the Academy and took office on 7 May 2010 for a four-year term, replacing the former president, Professor Kurt Lambeck. Cory was the Director of the

(WEHI), from 1996 until 30 June 2009 and remains a faculty member, having rejoined the institute's Molecular Genetics of Cancer Division. Her current research focuses on genetic changes in blood cancers and the effects of chemotherapeutic drugs on the cancer cells. Cory's work has been published in ''

Blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood is com ...

'', ''

The EMBO Journal ''The EMBO Journal'' is a semi-monthly peer-reviewed scientific journal focusing on full-length papers describing original research of general interest in molecular biology and related areas. The editor-in-chief is Facundo D. Batista ( Harvard Medi ...

'', ''

Nature Nature is an inherent character or constitution, particularly of the Ecosphere (planetary), ecosphere or the universe as a whole. In this general sense nature refers to the Scientific law, laws, elements and phenomenon, phenomena of the physic ...

'', '' Cell Death & Differentiation'', and ''

Proceedings of the National Academy of Sciences of the United States of America ''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Scie ...

''. The Suzanne Cory High School opened in Cory's honour in 2011. The public high school caters to 800 students from grades 9-12. The school is in close proximity to Victoria University, which allows students access to the school's facilities and staff. In 2021, the Australian Academy of Science created the Suzanne Cory Medal for Biomedical Sciences, awarded for outstanding research in all of the biological sciences.

Awards and honors

*1986 — elected a

Fellow of the Australian Academy of Science The Fellowship of the Australian Academy of Science is made up of about 500 Australian scientists. Scientists judged by their peers to have made an exceptional contribution to knowledge in their field may be elected to Fellowship of the Academy ...

(FAA) *1992 — elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

(FRS) *1995 — awarded

Lemberg Medal The Lemberg Medal, named after Max Rudolf Lemberg, the first president of the Australian Society for Biochemistry and Molecular Biology (ASBMB), is awarded annually to a scientist who has been a member for five or more years and who has "demonstr ...

*1997 — awarded

Macfarlane Burnet Medal and Lecture The Macfarlane Burnet Medal and Lecture is a biennial award given by the Australian Academy of Science to recognise outstanding scientific research in the biological sciences. It was established in 1971 and honours the memory of the Nobel laureat ...

of the

*1997 — elected Fellow of the

Royal Society of Victoria The Royal Society of Victoria (RSV) is the oldest scientific society in Victoria, Australia. Foundation In 1854 two organisations formed with similar aims and membership, these being the Victorian Institute for the Advancement of Science (found ...

(FRSV) *1998 — received Charles S. Mott Prize of the General Motors Cancer Research Foundation (joint recipient) *1999 — named a

Companion of the Order of Australia The Order of Australia is an Australian honours and awards system, Australian honour that recognises Australian citizens and other persons for outstanding achievement and service. It was established on 14 February 1975 by Elizabeth II, Monarch ...

(AC) *2001 — recipient of a L'Oréal-UNESCO Award for Women in Science *2001 — inducted onto

Victorian Honour Roll of Women The Victorian Honour Roll of Women was established in 2001 to recognise the achievements of women from the Australian state of Victoria. It was launched by The Hon. Joan Kirner AC as a joint initiative of the Centenary of Federation Victoria Comm ...

*2002 — awarded the

Royal Medal The Royal Medal, also known as The Queen's Medal and The King's Medal (depending on the gender of the monarch at the time of the award), is a silver-gilt medal, of which three are awarded each year by the Royal Society. Two are given for "the mo ...

of the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

*2004 — elected an Academician of the

Pontifical Academy of Sciences The Pontifical Academy of Sciences (, ) is a Academy of sciences, scientific academy of the Vatican City, established in 1936 by Pope Pius XI. Its aim is to promote the progress of the mathematical, physical, and natural sciences and the study ...

*2009 — named a

Chevalier of the Legion of Honor The National Order of the Legion of Honour ( ), formerly the Imperial Order of the Legion of Honour (), is the highest and most prestigious French national order of merit, both military and Civil society, civil. Currently consisting of five cl ...

and was presented with her award in Canberra, Australia, by the Ambassador of France in Australia, Michel Filhol *2011 — awarded the Association for International Cancer Research Colin Thomson Medal *2012 — winner, CSIRO Eureka Prize for Leadership in Science *2013 — elected as a Fellow of the inaugural Class of the

American Association for Cancer Research The American Association for Cancer Research (AACR) is the world's oldest and largest professional association related to cancer research. Based in Philadelphia, the AACR focuses on all aspects of cancer research, including Basic research, basic, ...

(AACR) Academy *2014 — delivered the annual ABC

Boyer Lectures The Boyer Lectures are a series of talks by prominent Australians, presenting ideas on major social, scientific or cultural issues, and broadcast on ABC Radio National. The Boyer Lectures began in 1959 as the ABC (Australian Broadcasting Commi ...

*2021 — elected Fellow of the

Australian Academy of Health and Medical Sciences The Australian Academy of Health and Medical Sciences is an academy to promote health and medical sciences in Australia. It was established in June 2014. It cites "The Academy will serve the three purposes identified as of high priority in the 2 ...

Personal life

During her time at the LMB, Cory met Jerry Adams, a scientist from the United States. The two scientists later married and had two daughters.

References

External links

* Overview o
directorship
an
research
at the Walter and Eliza Hall Institute. * Smith, Deborah

''

The Age ''The Age'' is a daily newspaper in Melbourne, Australia, that has been published since 1854. Owned and published by Nine Entertainment, ''The Age'' primarily serves Victoria (Australia), Victoria, but copies also sell in Tasmania, the Austral ...

'', 7 August 2010. *
Suzanne Cory on Women in Science: International Differences
CSHL Digital Archives {{DEFAULTSORT:Cory, Suzanne Australian medical researchers Australian women scientists Australian women medical researchers 1942 births Living people Australia Prize recipients Knights of the Legion of Honour Companions of the Order of Australia Fellows of the Australian Academy of Science Fellows of the Royal Society Australian fellows of the Royal Society Female fellows of the Royal Society L'Oréal-UNESCO Awards for Women in Science laureates Foreign associates of the National Academy of Sciences Members of the French Academy of Sciences Members of the Pontifical Academy of Sciences Presidents of the Australian Academy of Science Royal Medal winners People educated at University High School, Melbourne WEHI alumni Place of birth missing (living people) 20th-century Australian biologists 21st-century Australian scientists 21st-century Australian biologists 20th-century American women scientists 21st-century American women scientists Fellows of the AACR Academy Fellows of the Australian Academy of Health and Medical Sciences People from Kew, Victoria Scientists from Melbourne People educated at Canterbury Girls' Secondary College