Susumu Hagiwara (; November 6, 1922 – April 1, 1989) was a Japanese-born American physician and

neuroscientist A neuroscientist (or neurobiologist) is a scientist specializing in neuroscience that deals with the anatomy and function of neurons, Biological neural network, neural circuits, and glia, and their Behavior, behavioral, biological, and psycholo ...

.Los Angeles Times:Susumu Hagiwara; Medical Pioneer, UCLA Professor, April 17, 1989
/ref> http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/hagiwara-susumu.pdf Hagiwara was born and raised in

Hokkaido is the list of islands of Japan by area, second-largest island of Japan and comprises the largest and northernmost prefectures of Japan, prefecture, making up its own list of regions of Japan, region. The Tsugaru Strait separates Hokkaidō fr ...

Japan Japan is an island country in East Asia. Located in the Pacific Ocean off the northeast coast of the Asia, Asian mainland, it is bordered on the west by the Sea of Japan and extends from the Sea of Okhotsk in the north to the East China Sea ...

, attending the

University of Tokyo The University of Tokyo (, abbreviated as in Japanese and UTokyo in English) is a public research university in Bunkyō, Tokyo, Japan. Founded in 1877 as the nation's first modern university by the merger of several pre-westernisation era ins ...

for his

M.D. A Doctor of Medicine (abbreviated MD, from the Latin ) is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the ''MD'' denotes a professional degree of physician. This ge ...

and Ph.D. degrees. He became a professor at the

Tokyo Medical and Dental University was a public university in Bunkyō, Tokyo, Japan. It merged with the Tokyo Institute of Technology to form the Institute of Science Tokyo on 1 October 2024. Established in 1928, Tokyo Medical and Dental University was the oldest national schoo ...

before migrating to the United States to serve as professor for both the

University of California, San Diego The University of California, San Diego (UC San Diego in communications material, formerly and colloquially UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California, United States. Es ...

and

University of California, Los Angeles The University of California, Los Angeles (UCLA) is a public university, public Land-grant university, land-grant research university in Los Angeles, California, United States. Its academic roots were established in 1881 as a normal school the ...

. The ''

Los Angeles Times The ''Los Angeles Times'' is an American Newspaper#Daily, daily newspaper that began publishing in Los Angeles, California, in 1881. Based in the Greater Los Angeles city of El Segundo, California, El Segundo since 2018, it is the List of new ...

'' called Hagiwara "a pioneer in understanding the mechanisms of excitability in nerve and muscle cells".

University of California The University of California (UC) is a public university, public Land-grant university, land-grant research university, research university system in the U.S. state of California. Headquartered in Oakland, California, Oakland, the system is co ...

called him the world's "most distinguished neuroscientist".University of California: In memoriam:Susumu Hagiwara, Neuroscience: Los Angeles
/ref> Dr. Kenneth Shine, dean of the

UCLA School of Medicine The UCLA School of Medicine (also known as the David Geffen School of Medicine at UCLA) is the accredited medical school of the University of California, Los Angeles. Founded in 1951, it is the second medical school in the University of Califor ...

, said: "Susumu Hagiwara revolutionized our understanding of how

calcium Calcium is a chemical element; it has symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar to it ...

moves across

cell membranes The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extra ...

, basic discoveries which lead to the calcium-blocking agents currently used to treat patients with

heart disease Cardiovascular disease (CVD) is any disease involving the heart or blood vessels. CVDs constitute a class of diseases that includes: coronary artery diseases (e.g. angina pectoris, angina, myocardial infarction, heart attack), heart failure, ...

migraine Migraine (, ) is a complex neurological disorder characterized by episodes of moderate-to-severe headache, most often unilateral and generally associated with nausea, and light and sound sensitivity. Other characterizing symptoms may includ ...

and

stroke Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemor ...

". Hagiwara was a member of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...

. He was also a member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

, a recipient of the Kenneth Cole Award of the

Biophysical Society The Biophysical Society is an international scientific society whose purpose is to lead the development and dissemination of knowledge in biophysics. Founded in 1958, the Society currently consists of over 7,000 members in academia, government, an ...

, a holder of an honorary doctorate from the

Universite Pierre et Marie Curie Pierre and Marie Curie University ( , UPMC), also known as Paris VI, was a public university, public research university in Paris, France, from 1971 to 2017. The university was located on the Jussieu Campus in the Latin Quarter of the 5th arrondi ...

in Paris, a recipient of the Ralph W. Gerard Prize in Neuroscience of the

Society for Neuroscience The Society for Neuroscience (SfN) is a professional society, headquartered in Washington, D.C., for basic scientists and physicians around the world whose research is focused on the study of the brain and nervous system. It is especially well k ...

Society for Neuroscience:Past Award Recipient List
/ref> and, posthumously, the

Order of the Rising Sun The is a Japanese honors system, Japanese order, established in 1875 by Emperor Meiji. The Order was the first national decoration awarded by the Japanese government, created on 10 April 1875 by decree of the Council of State. The badge feat ...

from the Japanese government. Hagiwara died of a

heart attack A myocardial infarction (MI), commonly known as a heart attack, occurs when Ischemia, blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle. The most common symptom ...

at his Los Angeles home on April 1, 1989.

References

{{DEFAULTSORT:Hagiwara, Susumu 1922 births 1989 deaths American neuroscientists Members of the United States National Academy of Sciences Scientists from Hokkaido Academic staff of Tokyo Medical and Dental University University of Tokyo alumni University of California, San Diego faculty David Geffen School of Medicine at UCLA faculty Japanese emigrants to the United States