chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules a ...

, a suspension is a

heterogeneous mixture In chemistry, a mixture is a material made up of two or more different chemical substances which can be separated by physical method. It is an impure substance made up of 2 or more elements or compounds mechanically mixed together in any proporti ...

of a

fluid In physics, a fluid is a liquid, gas, or other material that may continuously motion, move and Deformation (physics), deform (''flow'') under an applied shear stress, or external force. They have zero shear modulus, or, in simpler terms, are M ...

that contains

solid Solid is a state of matter where molecules are closely packed and can not slide past each other. Solids resist compression, expansion, or external forces that would alter its shape, with the degree to which they are resisted dependent upon the ...

particle In the physical sciences, a particle (or corpuscle in older texts) is a small localized object which can be described by several physical or chemical properties, such as volume, density, or mass. They vary greatly in size or quantity, from s ...

s sufficiently large for

sedimentation Sedimentation is the deposition of sediments. It takes place when particles in suspension settle out of the fluid in which they are entrained and come to rest against a barrier. This is due to their motion through the fluid in response to th ...

. The particles may be visible to the

naked eye Naked eye, also called bare eye or unaided eye, is the practice of engaging in visual perception unaided by a magnification, magnifying, Optical telescope#Light-gathering power, light-collecting optical instrument, such as a telescope or microsc ...

, usually must be larger than one micrometer, and will eventually

settle Settle or SETTLE may refer to: __NOTOC__ Places * Settle, Kentucky, United States, an unincorporated community * Settle, North Yorkshire, a town in England ** Settle Rural District, a historical administrative district Music * Settle (band), an in ...

, although the

mixture In chemistry, a mixture is a material made up of two or more different chemical substances which can be separated by physical method. It is an impure substance made up of 2 or more elements or compounds mechanically mixed together in any proporti ...

is only classified as a suspension when and while the particles have not settled out.

Properties

A suspension is a heterogeneous mixture in which the

particles do not dissolve, but get suspended throughout the bulk of the

solvent A solvent (from the Latin language, Latin ''wikt:solvo#Latin, solvō'', "loosen, untie, solve") is a substance that dissolves a solute, resulting in a Solution (chemistry), solution. A solvent is usually a liquid but can also be a solid, a gas ...

, left floating around freely in the medium. The internal phase (solid) is dispersed throughout the external phase (fluid) through mechanical agitation, with the use of certain

excipients An excipient is a substance formulated alongside the active ingredient of a medication. They may be used to enhance the active ingredient’s therapeutic properties; to facilitate drug absorption; to reduce viscosity; to enhance solubility; to i ...

or suspending agents. An example of a suspension would be sand in water. The suspended particles are visible under a

microscope A microscope () is a laboratory equipment, laboratory instrument used to examine objects that are too small to be seen by the naked eye. Microscopy is the science of investigating small objects and structures using a microscope. Microscopic ...

and will settle over time if left undisturbed. This distinguishes a suspension from a

colloid A colloid is a mixture in which one substance consisting of microscopically dispersed insoluble particles is suspended throughout another substance. Some definitions specify that the particles must be dispersed in a liquid, while others exte ...

, in which the

particles are smaller and do not settle. Colloids and suspensions are different from

solution Solution may refer to: * Solution (chemistry), a mixture where one substance is dissolved in another * Solution (equation), in mathematics ** Numerical solution, in numerical analysis, approximate solutions within specified error bounds * Solu ...

, in which the dissolved substance (solute) does not exist as a solid, and solvent and solute are homogeneously mixed. A suspension of liquid droplets or fine solid particles in a gas is called an

aerosol An aerosol is a suspension (chemistry), suspension of fine solid particles or liquid Drop (liquid), droplets in air or another gas. Aerosols can be generated from natural or Human impact on the environment, human causes. The term ''aerosol'' co ...

. In the

atmosphere An atmosphere () is a layer of gases that envelop an astronomical object, held in place by the gravity of the object. A planet retains an atmosphere when the gravity is great and the temperature of the atmosphere is low. A stellar atmosph ...

, the suspended particles are called

particulates Particulate matter (PM) or particulates are microscopic particles of solid or liquid matter suspension (chemistry), suspended in the atmosphere of Earth, air. An ''aerosol'' is a mixture of particulates and air, as opposed to the particulate ...

and consist of fine dust and

soot Soot ( ) is a mass of impure carbon particles resulting from the incomplete combustion of hydrocarbons. Soot is considered a hazardous substance with carcinogenic properties. Most broadly, the term includes all the particulate matter produced b ...

particles,

sea salt Sea salt is salt that is produced by the evaporation of seawater. It is used as a seasoning in foods, cooking, cosmetics and for preserving food. It is also called bay salt, solar salt, or simply salt. Like mined rock salt, production of sea sal ...

biogenic A biogenic substance is a product made by or of life forms. While the term originally was specific to metabolite compounds that had toxic effects on other organisms, it has developed to encompass any constituents, secretions, and metabolites of p ...

and

volcano A volcano is commonly defined as a vent or fissure in the crust of a planetary-mass object, such as Earth, that allows hot lava, volcanic ash, and gases to escape from a magma chamber below the surface. On Earth, volcanoes are most oft ...

genic

sulfate The sulfate or sulphate ion is a polyatomic anion with the empirical formula . Salts, acid derivatives, and peroxides of sulfate are widely used in industry. Sulfates occur widely in everyday life. Sulfates are salts of sulfuric acid and many ...

nitrate Nitrate is a polyatomic ion with the chemical formula . salt (chemistry), Salts containing this ion are called nitrates. Nitrates are common components of fertilizers and explosives. Almost all inorganic nitrates are solubility, soluble in wa ...

s, and

cloud In meteorology, a cloud is an aerosol consisting of a visible mass of miniature liquid droplets, frozen crystals, or other particles, suspended in the atmosphere of a planetary body or similar space. Water or various other chemicals may ...

droplets. Suspensions are classified on the basis of the

dispersed phase Dispersion may refer to: Economics and finance *Dispersion (finance), a measure for the statistical distribution of portfolio returns * Price dispersion, a variation in prices across sellers of the same item *Wage dispersion, the amount of variat ...

and the

dispersion medium Interface and colloid science is an interdisciplinary intersection of branches of chemistry, physics, nanoscience and other fields dealing with ''colloids'', heterogeneous systems consisting of a mechanical mixture of particles between 1 nm ...

, where the former is essentially solid while the latter may either be a solid, a liquid, or a gas. In modern chemical process industries, high-shear mixing technology has been used to create many novel suspensions. Suspensions are unstable from a thermodynamic point of view but can be kinetically stable over a longer period of time, which in turn can determine a suspension's shelf life. This time span needs to be measured in order to provide accurate information to the consumer and ensure the best product quality. "Dispersion stability refers to the ability of a dispersion to resist change in its properties over time."

Technique monitoring physical stability

Multiple light scattering coupled with vertical scanning is the most widely used technique to monitor the dispersion state of a product, hence identifying and quantifying

destabilization The word destabilisation (alternatively, destabilization) can be applied to a wide variety of contexts such as attempts to undermine political, military or economic power. Psychology In a psychological context, it is used as a technique in brai ...

phenomena. It works on concentrated dispersions without dilution. When light is sent through the sample, it is back scattered by the particles. The backscattering intensity is directly proportional to the size and volume fraction of the dispersed phase. Therefore, local changes in concentration (

) and global changes in size (

flocculation In colloidal chemistry, flocculation is a process by which colloidal particles come out of Suspension (chemistry), suspension to sediment in the form of floc or flake, either spontaneously or due to the addition of a clarifying agent. The actio ...

, aggregation) are detected and monitored. Of primary importance in the analysis of stability in particle suspensions is the value of the

zeta potential Zeta potential is the electrical potential at the slipping plane. This plane is the interface which separates mobile fluid from fluid that remains attached to the surface.is a scientific term for Electrokinetic phenomena, electrokinetic Electric ...

exhibited by suspended solids. This parameter indicates the magnitude of interparticle electrostatic repulsion and is commonly analyzed to determine how the use of adsorbates and pH modification affect particle repulsion and suspension stabilization or destabilization.

Accelerating methods for shelf life prediction

The kinetic process of destabilisation can be rather long (up to several months or even years for some products) and it is often required for the formulator to use further accelerating methods in order to reach reasonable development time for new product design. Thermal methods are the most commonly used and consists in increasing temperature to accelerate destabilisation (below critical temperatures of phase and degradation). Temperature affects not only the viscosity, but also interfacial tension in the case of non-ionic surfactants or more generally interactions forces inside the system. Storing a dispersion at high temperatures enables simulation of real life conditions for a product (e.g. tube of sunscreen cream in a car in the summer), but also to accelerate destabilisation processes up to 200 times including vibration,

centrifugation Centrifugation is a mechanical process which involves the use of the centrifugal force to separate particles from a solution according to their size, shape, density, medium viscosity and rotor speed. The denser components of the mixture migrate ...

and agitation are sometimes used. They subject the product to different forces that pushes the particles / film drainage. However, some emulsions would never coalesce in normal gravity, while they do under artificial gravity. Moreover, segregation of different populations of particles have been highlighted when using centrifugation and vibration.P. Snabre, B. Pouligny Langmuir, 24 (2008) 13338-13347

Examples

Common examples of suspensions include: *

Mud Mud (, or Middle Dutch) is loam, silt or clay mixed with water. Mud is usually formed after rainfall or near water sources. Ancient mud deposits hardened over geological time to form sedimentary rock such as shale or mudstone (generally cal ...

or muddy water: where soil, clay, or silt particles are suspended in water. *

Flour Flour is a powder made by Mill (grinding), grinding raw grains, List of root vegetables, roots, beans, Nut (fruit), nuts, or seeds. Flours are used to make many different foods. Cereal flour, particularly wheat flour, is the main ingredie ...

suspended in water. *

Kimchi Kimchi (; ) is a traditional Korean side dish (''banchan'') consisting of salted and fermented vegetables, most often napa cabbage or Korean radish. A wide selection of seasonings are used, including '' gochugaru'' (Korean chili powder), ...

suspended on vinegar. *

Chalk Chalk is a soft, white, porous, sedimentary carbonate rock. It is a form of limestone composed of the mineral calcite and originally formed deep under the sea by the compression of microscopic plankton that had settled to the sea floor. Ch ...

suspended in water. *

Sand Sand is a granular material composed of finely divided mineral particles. Sand has various compositions but is usually defined by its grain size. Sand grains are smaller than gravel and coarser than silt. Sand can also refer to a textural ...

suspended in water.

References

{{DEFAULTSORT:Suspension (Chemistry) Colloidal chemistry Drug delivery devices Dosage forms Heterogeneous chemical mixtures

Properties

Technique monitoring physical stability

Accelerating methods for shelf life prediction

Examples

See also

References