The Super Conserved Receptor Expressed in Brain (SREB) family are a group of related
G-protein coupled receptors
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
.
Since no
endogenous
Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.
In contrast, exogenous substances and processes are those that originate from outside of an organism.
For example, ...
ligands have yet been identified for these receptors, they are classified as
orphan receptor
In biochemistry, an orphan receptor is a protein that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified. If a ligand for an orphan receptor is later discovered, the receptor is referred t ...
s. Receptors within the group include SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173).
[National Center for Biotechnology Information]
Conserved Protein Domain Family
7tmA_SREB1_GPR27
accessed 5 February 2022
References
External links
IUPHAR GPCR Database - GPR27 (previously SREB1)IUPHAR GPCR Database - GPR85 (previously SREB2)IUPHAR GPCR Database - GPR173 (previously SREB3)*
*
G protein-coupled receptors
{{transmembranereceptor-stub