Suloctidil was a sulfur-containing
aminoalcohol
In organic chemistry, alkanolamines are organic compounds that contain both hydroxyl () and amino (, , and ) functional groups on an alkane backbone. The term alkanolamine is a broad class term that is sometimes used as a subclassification.
Meth ...
that was brought to market in the early 1970s as a
vasodilator
Vasodilation is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. The process is the opposite of vasoconstriction ...
by Continental Pharma, a Belgian company.
Continental was bought by
Monsanto
The Monsanto Company () was an American agrochemical and agricultural biotechnology corporation founded in 1901 and headquartered in Creve Coeur, Missouri. Monsanto's best known product is Roundup, a glyphosate-based herbicide, developed i ...
in 1984, primarily on the promise of sales of suloctidil, which was approved in Europe at the time, but not in the US. However, in 1985 Monsanto halted development and withdrew the drug worldwide following reports of
liver toxicity.
References
Hepatotoxins
Phenylethanolamines
Substituted amphetamines
Thioethers
Withdrawn drugs
Alcohols
Isopropyl compounds
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